Bell D A, Scully R E
Cancer. 1985 Dec 15;56(12):2922-31. doi: 10.1002/1097-0142(19851215)56:12<2922::aid-cncr2820561233>3.0.co;2-l.
The criteria for the diagnosis of benign and borderline clear cell adenofibromas and their biologic behavior were investigated by examination of the clinical and pathologic features of 18 tumors in these categories. Three tumors that showed no significant epithelial atypicality were classified as benign. Twelve tumors that contained glands or small solid nests composed of epithelial cells with nuclear characteristics of low-grade malignancy without invasion of the stromal component of the tumor were designated as borderline. Three predominantly borderline tumors with focal microinvasion of the stromal component were also studied. The 17 patients had nonspecific complaints. Sixteen of the tumors were unilateral without surface involvement; one patient had bilateral borderline tumors. Most of the women were treated by hysterectomy and bilateral salpingo-oophorectomy. Follow-up information was available for 16 of the 17 patients. No recurrences or deaths from tumor occurred in 14 patients (2 benign, 10 borderline, 2 microinvasive). One patient with a borderline adenofibroma had questionable lung metastasis 4 years after presentation, and another patient who had a microinvasive tumor had a pelvic recurrence 3.3 years postoperatively.
通过检查18例此类肿瘤的临床和病理特征，研究了良性及交界性透明细胞腺纤维瘤的诊断标准及其生物学行为。3例无明显上皮异型性的肿瘤被分类为良性。12例肿瘤含有由具有低级别恶性核特征的上皮细胞组成的腺体或小实性巢，且未侵犯肿瘤的间质成分，被指定为交界性。还研究了3例主要为交界性且有局灶性间质微浸润的肿瘤。17例患者有非特异性主诉。16例肿瘤为单侧，未累及表面；1例患者有双侧交界性肿瘤。大多数女性接受了子宫切除术和双侧输卵管卵巢切除术。17例患者中有16例有随访信息。14例患者（2例良性、10例交界性、2例微浸润性）无肿瘤复发或死亡。1例交界性腺纤维瘤患者在就诊4年后有可疑的肺转移，另1例有微浸润性肿瘤的患者在术后3.3年出现盆腔复发。
