Bell D A, Scully R E
Am J Surg Pathol. 1985 Mar;9(3):205-14. doi: 10.1097/00000478-198503000-00004.
The significance of varying degrees of epithelial atypicality was investigated in 27 endometrioid adenofibromas and cystadenofibromas of the ovary. The tumors were classified as atypical or borderline on the basis of the degree of atypicality of the epithelial element. All tumors were confined to the ovary at the initial operation and most of them were treated by a hysterectomy and bilateral salpingo-oophorectomy. Seven tumors with mild to severe cytologic and architectural atypicality similar to that encountered in atypical endometrial hyperplasia were classified as atypical adenofibromas. No recurrences or deaths from tumor occurred in patients with this type of tumor during 1-18.5 years of follow-up. Twenty tumors that contained closely packed glands or epithelial islands with a cribriform pattern composed of cells with low-grade malignant nuclear characteristics embedded in an abundant fibromatous stroma without evidence of invasion were classified as borderline. Nineteen patients with tumors of this type had no evidence of disease 1-13 years after initial therapy. One of these tumors was discovered at autopsy. These data, although based on a relatively small series of cases, suggest that atypical endometrioid adenofibromas and those of borderline malignancy have an excellent prognosis.
对27例卵巢子宫内膜样腺纤维瘤和囊腺纤维瘤中不同程度上皮细胞非典型性的意义进行了研究。根据上皮成分的非典型程度，将肿瘤分为非典型或临界性肿瘤。所有肿瘤在初次手术时均局限于卵巢，大多数患者接受了子宫切除术和双侧输卵管卵巢切除术。7例具有轻度至重度细胞学和结构非典型性、类似于非典型子宫内膜增生所见的肿瘤被归类为非典型腺纤维瘤。在1至18.5年的随访期间，患有此类肿瘤的患者未出现肿瘤复发或死亡。20例肿瘤含有紧密排列的腺体或上皮岛，呈筛状结构，由具有低级别恶性核特征的细胞组成，嵌入丰富的纤维瘤样间质中，无浸润证据，被归类为临界性肿瘤。19例患有此类肿瘤的患者在初始治疗后1至13年无疾病证据。其中1例肿瘤在尸检时被发现。这些数据虽然基于相对较少的病例系列，但表明非典型子宫内膜样腺纤维瘤和临界恶性肿瘤具有良好的预后。
