Rong Xuewen, Yu Dongting, Zhao Wei, Xiao Jingyu, Feng Du, Chen Gengfeng, Cao Zemeng, Shu Liming
Nanshan School, Guangzhou Medical University, Guangzhou, China.
School of Pediatrics, Guangzhou Medical University, Guangzhou, China.
Front Public Health. 2025 Jun 2;13:1598497. doi: 10.3389/fpubh.2025.1598497. eCollection 2025.
Idiopathic epilepsy is a major global health burden that causes premature death and disability. Previous studies have systematically analyzed trends in the burden of idiopathic epilepsy. However, analyses of the impact of social factors, health campaigns and policies on the burden of idiopathic epilepsy are lacking. This study aims to fill that gap.
We used data from the 2021 Global Burden of Disease (GBD) and calculated the estimated annual percentage changes (EAPC) to assess trends. Decomposition analysis breaks down changes in the burden of idiopathic epilepsy into three factors. Correlation analysis measures the association between the EAPC and social development. Inequality analysis illustrates the disparity in the burden of idiopathic epilepsy among countries. Generalized difference-in-differences (GDID) and synthetic difference-in-differences (SDID) analyses are used to quantify the impact of health campaigns or policies on the burden of idiopathic epilepsy.
With respect to incidence, aging had a negative impact. The correlation between the sociodemographic index (SDI) and EAPC had a rho value of -0.18. The slope index of inequality for the mortality burden decreased from 1.97 to 1.62. After the policy shock, the age-standardized rate (ASR) of years lived with disability (YLD) in the Caribbean increased significantly to 4.59 (95% CI: 0.96 to 8.22), while the all-age YLD rate in the U.S. increased (5.18, 95% CI: 0.66 to 9.70) for both sexes.
This study explores the impact of social factors and health campaigns on the burden of idiopathic epilepsy. We emphasize the need for targeted prevention and treatment strategies to effectively address the burden of idiopathic epilepsy.
特发性癫痫是一项重大的全球健康负担，可导致过早死亡和残疾。以往的研究已系统分析了特发性癫痫负担的趋势。然而，缺乏对社会因素、健康运动及政策对特发性癫痫负担影响的分析。本研究旨在填补这一空白。
我们使用了2021年全球疾病负担（GBD）的数据，并计算了估计年度百分比变化（EAPC）以评估趋势。分解分析将特发性癫痫负担的变化分解为三个因素。相关性分析衡量EAPC与社会发展之间的关联。不平等分析阐明了各国在特发性癫痫负担方面的差异。广义差分法（GDID）和合成差分法（SDID）分析用于量化健康运动或政策对特发性癫痫负担的影响。
在发病率方面，老龄化有负面影响。社会人口指数（SDI）与EAPC之间的相关性rho值为 -0.18。死亡率负担的不平等斜率指数从1.97降至1.62。政策冲击后，加勒比地区残疾调整生命年（YLD）的年龄标准化率（ASR）显著增至4.59（95%置信区间：0.96至8.22），而美国所有年龄段的YLD率在两性中均有所上升（5.18，95%置信区间：0.66至9.70）。
本研究探讨了社会因素和健康运动对特发性癫痫负担的影响。我们强调需要有针对性的预防和治疗策略，以有效应对特发性癫痫的负担。
