Wang Tianchi, Sun Jiabo, Teng Zhaowei, Yao Shuyi, Yuan Junheng, Han Lulu, Mu Dedan, Song Hao, Yu Xue, Xu Xuhui
The Central Laboratory and Department of Orthopedic The Second Affiliated Hospital of Kunming Medical University Kunming Yunnan 650106 P. R. China.
Faculty of Materials Science and Engineering Key Laboratory of Advanced Materials of Yunnan Province Kunming University of Science and Technology Kunming Yunnan 650093 P. R. China.
Small Sci. 2025 Feb 21;5(6):2500033. doi: 10.1002/smsc.202500033. eCollection 2025 Jun.
Bioimaging with remarkable noninvasive nature, ultrahigh resolution and sensitivity allows detection of pathologies of bones, organs, and tissues. Nevertheless, the achievement of more complete information in vivo is challenged by the necessity of multiple photodetectors with diverse response ranges. Herein, a multifunctional bioimaging with CsAgInCl:Yb perovskites via a single InGaAs detector for superior tissue presentation is realized in this work. Co-incorporation of foreign dopant contributes to alterations of local structural symmetry of the CsAgInCl host, disruption of parity-forbidden transitions, and reduction in electron-phonon coupling strength, thereby boosting the near-infrared (NIR) intensity by 40-fold of the corresponding perovskites drastically. Moreover, an X-ray excited NIR light output is 2.83 times that of commercial BiGeO scintillators. Thanks to the efficient NIR emission, the versatile perovskites film endows a multifunctional bioimaging with detailed information of biological tissue in vivo, which fundamentally offers viable avenues for promoting bioimaging technology with integrated access of tissue presentation.
具有非凡的非侵入性、超高分辨率和灵敏度的生物成像技术能够检测骨骼、器官和组织的病变。然而，由于需要多种具有不同响应范围的光电探测器，在体内获取更完整信息面临挑战。在此工作中，通过单个铟镓砷探测器实现了基于CsAgInCl:Yb钙钛矿的多功能生物成像，以实现卓越的组织呈现。外来掺杂剂的共掺入有助于改变CsAgInCl主体的局部结构对称性、破坏宇称禁戒跃迁以及降低电子 - 声子耦合强度，从而使相应钙钛矿的近红外（NIR）强度急剧提高40倍。此外，X射线激发的近红外光输出是商用BiGeO闪烁体的2.83倍。得益于高效的近红外发射，多功能钙钛矿薄膜赋予了体内生物组织详细信息的多功能生物成像，从根本上为通过综合组织呈现促进生物成像技术提供了可行途径。
