Perugini Enrico, Ascoli Bartoli Tommaso, Carrara Stefania, Maffongelli Gaetano, Scorzolini Laura
Infectious Diseases Unit, Department of System Medicine, Tor Vergata University, 00133 Rome, Italy.
National Institute for Infectious Diseases "Lazzaro Spallanzani"-IRCCS, 00149 Rome, Italy.
One Health. 2025 Jun 1;20:101097. doi: 10.1016/j.onehlt.2025.101097. eCollection 2025 Jun.
Leptospirosis is a re-emerging zoonotic disease that poses significant threats. Its nonspecific symptoms can mimic other febrile illnesses, complicating diagnosis, especially in low-endemic regions like Europe, where clinical awareness among healthcare providers may be limited. Diagnostic challenges also arise in low-resource settings due to restricted access to appropriate testing. Specific antimicrobials are the cornerstone of medical treatment, while the role of systemic steroids in severe cases remains undefined. We present a case of severe sepsis and pneumonia caused by in a previously healthy 23-year-old male from Cuba. The main characteristics of the case include severe lung involvement, with the development of respiratory failure despite two days of potentially effective antimicrobial therapy, and the favorable outcome achieved with a combination of intravenous steroids, targeted antibiotic treatment and supportive measures.
钩端螺旋体病是一种再度出现且构成重大威胁的人畜共患病。其非特异性症状可类似其他发热性疾病，使诊断复杂化，尤其是在欧洲等低流行地区，医疗服务提供者的临床意识可能有限。由于在资源匮乏地区难以获得适当检测，诊断也面临挑战。特定抗菌药物是医学治疗的基石，而全身用类固醇在重症病例中的作用仍不明确。我们报告一例由 引起的严重脓毒症和肺炎病例，患者为一名来自古巴的23岁既往健康男性。该病例的主要特征包括严重肺部受累，尽管进行了两天可能有效的抗菌治疗仍出现呼吸衰竭，以及通过静脉注射类固醇、针对性抗生素治疗和支持措施联合应用取得了良好预后。 （原文中“in a previously healthy 23-year-old male from Cuba. The main characteristics of the case include severe lung involvement, with the development of respiratory failure despite two days of potentially effective antimicrobial therapy, and the favorable outcome achieved with a combination of intravenous steroids, targeted antibiotic treatment and supportive measures.”这段内容中“in a previously healthy 23-year-old male from Cuba.”后面似乎缺少关键信息，不太明确具体是什么病原体导致的病症。）
