Shapoo Nidha, Chalabi Jumana, Huang Paul, Lieberman Seth, Boma Noella
Internal Medicine, New York Medical College, Metropolitan Hospital Center, New York, USA.
Neurosurgery, New York Medical College/Bellevue Hospital, New York, USA.
Cureus. 2025 May 18;17(5):e84327. doi: 10.7759/cureus.84327. eCollection 2025 May.
Invasive sino-orbital aspergillosis is a rare but potentially fatal fungal infection that predominantly affects immunocompromised individuals. It can lead to severe complications such as internal carotid artery invasion and ischemic stroke. We report a case of a 74-year-old male patient with uncontrolled diabetes mellitus who presented with right eye pain and proptosis. Imaging revealed a sino-orbital mass with invasion into the cavernous sinus and internal carotid artery. Following a biopsy, the patient suffered an ischemic stroke due to the right internal carotid artery occlusion, requiring mechanical thrombectomy and stent placement. Histopathology confirmed , and the patient was treated with amphotericin B and voriconazole, showing improvement. This case highlights the importance of early diagnosis and a multidisciplinary approach in managing invasive sino-orbital aspergillosis to prevent fatal vascular complications.
侵袭性鼻窦眼眶曲霉菌病是一种罕见但可能致命的真菌感染，主要影响免疫功能低下的个体。它可导致严重并发症，如颈内动脉侵袭和缺血性中风。我们报告一例74岁男性患者，患有未控制的糖尿病，出现右眼疼痛和眼球突出。影像学检查发现鼻窦眼眶肿块，侵犯海绵窦和颈内动脉。活检后，患者因右侧颈内动脉闭塞发生缺血性中风，需要进行机械取栓和支架置入。组织病理学确诊后，患者接受两性霉素B和伏立康唑治疗，病情有所改善。该病例强调了早期诊断和多学科方法在管理侵袭性鼻窦眼眶曲霉菌病以预防致命血管并发症方面的重要性。
