Wu Di, Liu Ye, Luo Xiaogang, Zhang Chengshou, Zheng Yifei, Meng Jianfeng, Yang Mei, Bisnauthsing Hemlata, Rao Ping, Ji Baohua, Chu Wai Kit
Eye Center, The Second Affiliated Hospital of Zhejiang University School of Medicine; Zhejiang Provincial Key Laboratory of Ophthalmology; Zhejiang Provincial Clinical Research Center for Eye Diseases; Zhejiang Provincial Engineering Institute on Eye Diseases, Hangzhou, China.
Institute of Biomechanics and Applications, Department of Engineering Mechanics, Zhejiang University, Hangzhou, China.
Adv Ophthalmol Pract Res. 2025 Apr 15;5(3):157-164. doi: 10.1016/j.aopr.2025.04.002. eCollection 2025 Aug-Sep.
The retina, a light-sensitive neural tissue critical for vision, exists in a dynamic mechanical environment where it is continuously exposed to mechanical forces. These forces, including traction forces, intraocular pressure-related stress, and hemodynamic forces, are closely linked to the progression of retinal diseases. A comprehensive understanding of retinal mechanosensation and mechanotransduction is essential for understanding the pathological mechanisms under aberrant mechanical conditions.
This review synthesizes current knowledge on advanced biomechanical assessment techniques, and aging-associated biomechanical alterations in retinal tissues, emphasizing how mechanical forces drive structural and functional pathology.
By elucidating the mechanosensitive mechanisms remodeling retinal cell behavior and fate, this review highlights the critical role of biomechanics in retinal disease pathogenesis. The integration of mechanistic insights with biomechanical assessment techniques offers transformative potential for diagnosing mechanical dysfunction and developing mechanotargeted therapies.
视网膜是一种对视觉至关重要的感光神经组织，存在于动态力学环境中，持续受到机械力作用。这些力包括牵引力、眼内压相关应力和血流动力学力，与视网膜疾病的进展密切相关。全面了解视网膜机械感觉和机械转导对于理解异常机械条件下的病理机制至关重要。
本综述综合了当前关于先进生物力学评估技术以及视网膜组织中与衰老相关的生物力学改变的知识，强调了机械力如何驱动结构和功能病理学。
通过阐明重塑视网膜细胞行为和命运的机械敏感机制，本综述突出了生物力学在视网膜疾病发病机制中的关键作用。将机制见解与生物力学评估技术相结合，为诊断机械功能障碍和开发机械靶向治疗提供了变革潜力。
