Zhu Jingyan, Li Xiaoqing, Lin Zhenhua, Qu Linzhuo, Guan Hongjian
Department of Neurology, Yanbian University Hospital, Yanji, 133000, China.
Key Laboratory of Pathobiology (Yanbian University), State Ethnic Affairs Commission, Yanji, 133000, China.
Discov Nano. 2025 Jun 18;20(1):96. doi: 10.1186/s11671-025-04277-9.
Glioblastoma (GBM) is the most common primary brain tumour in adults and poses a serious health risk. Graphene quantum dots (GQDs) are zero-dimensional crystalline discs de-rived from two-dimensional graphene, which contribution of GQDs in the treatment of GBM and the great potential for future development. In this study, the Web of Science database was applied to search 462 relevant papers published between 2009 and 2023, and analyzed using VOS viewer and CiteSpace software tools. This analysis aims to provide researchers with insights into the current state of applications and to facilitate a clearer understanding of potential pathways and directions for future research in this field. Our study showed a continuous increase in the number of papers about GQDs in the treatment of GBM. In the field for more than a decade, GQDs has been a research priority in drug delivery due to their excellent optical and chemical properties. It is reasonable to believe that the use of GQDs for drug delivery for the treatment of GBM will be-come one of the extremely important research topics in the future.
胶质母细胞瘤（GBM）是成人中最常见的原发性脑肿瘤，对健康构成严重风险。石墨烯量子点（GQDs）是从二维石墨烯衍生而来的零维晶体盘，其在GBM治疗中的作用以及未来发展的巨大潜力。在本研究中，应用科学网数据库检索了2009年至2023年间发表的462篇相关论文，并使用VOS viewer和CiteSpace软件工具进行分析。该分析旨在为研究人员提供对当前应用状态的见解，并促进对该领域未来研究的潜在途径和方向有更清晰的理解。我们的研究表明，关于GQDs治疗GBM的论文数量持续增加。在十多年的时间里，由于其优异的光学和化学性质，GQDs一直是药物递送领域的研究重点。有理由相信，使用GQDs进行药物递送治疗GBM将成为未来极其重要的研究课题之一。
