Satapathy Prakasini, Gaidhane Abhay M, Vadia Nasir, Menon Soumya V, Chennakesavulu Kattela, Panigrahi Rajashree, Kaur Manpreet, Bushi Ganesh, Shabil Muhammed, Jena Diptismita, Goyal Mayank, Kumar Harish, Rani Anju, Sah Sanjit, Goh Khang Wen
Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, India.
Faculty of Data Science and Information Technology, INTI International University, Nilai, Malaysia.
Brain Behav. 2025 Jun;15(6):e70647. doi: 10.1002/brb3.70647.
Suicidal ideation is a global public health concern, highlighting the need to identify modifiable risk factors. Handgrip strength (HGS), an objective measure of muscular strength, has been linked to mental health outcomes. This review synthesizes evidence on HGS and suicidal ideation, exploring modifiers such as sex.
This systematic review and meta-analysis, registered with PROSPERO and conducted in accordance with PRISMA guidelines, evaluated data retrieved from PubMed, Embase, and Web of Science up to November 30, 2024. The analysis focused on randomized controlled trials and observational studies-including case-control, cohort, and cross-sectional designs-that examined the relationship between HGS and suicidal ideation in human populations. A random-effects model was employed to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs). Heterogeneity among studies was assessed using the I statistic.
Out of 294 studies, 9 met the inclusion criteria for the systematic review, and 6 were eligible for meta-analysis, involving 81,035 participants. The pooled analysis showed a nonsignificant association between HGS and suicidal ideation. For males, the pooled OR per 1 kg increase in HGS was 0.939 (95% CI, 0.875-1.009), and for females, it was 0.851 (95% CI, 0.662-1.094), indicating a potential but nonsignificant protective effect.
This systematic review and meta-analysis found no statistically significant association between handgrip strength and suicidal ideation in the pooled analysis. However, consistent trends observed in the qualitative synthesis suggest a potential relationship that warrants further investigation. Longitudinal studies are essential to elucidate the underlying mechanisms.
自杀意念是一个全球公共卫生问题，凸显了识别可改变风险因素的必要性。握力（HGS）作为肌肉力量的客观指标，已与心理健康结果相关联。本综述综合了关于握力和自杀意念的证据，探讨了性别等调节因素。
本系统综述和荟萃分析已在PROSPERO注册，并按照PRISMA指南进行，评估了截至2024年11月30日从PubMed、Embase和科学网检索到的数据。分析集中于随机对照试验和观察性研究，包括病例对照、队列和横断面设计，这些研究考察了人群中握力与自杀意念之间的关系。采用随机效应模型计算合并优势比（OR）及95%置信区间（CI）。使用I统计量评估研究间的异质性。
在294项研究中，9项符合系统综述的纳入标准，6项符合荟萃分析的条件，涉及81,035名参与者。汇总分析显示握力与自杀意念之间无显著关联。对于男性，握力每增加1千克，合并OR为0.939（95%CI，0.875 - 1.009）；对于女性，合并OR为0.851（95%CI，0.662 - 1.094），表明存在潜在但不显著的保护作用。
本系统综述和荟萃分析在汇总分析中未发现握力与自杀意念之间存在统计学显著关联。然而，定性综合分析中观察到的一致趋势表明可能存在一种关系，值得进一步研究。纵向研究对于阐明潜在机制至关重要。
