Sakamoto Y, Himeno K, Sanui H, Yoshida S, Nomoto K
Clin Immunol Immunopathol. 1985 Dec;37(3):360-8. doi: 10.1016/0090-1229(85)90105-9.
Experimental allergic orchitis (EAO) was induced in cyclophosphamide (CY)-pretreated C3H/He mice by immunization with viable testicular cells (TC) without any adjuvants. The pathological changes such as hypospermatogenesis in the seminiferous tubules and mild cellular infiltration in the interstitium were observed in most mice thus treated. Delayed footpad reaction (DFR) against testicular antigen and anti-sperm antibody in sera were detected in those mice. This murine model of orchitis is new and simple in that no adjuvants are used for induction and can be useful in further studies on mechanisms of induction and maintenance of EAO.
通过用活的睾丸细胞（TC）免疫，在未使用任何佐剂的情况下，在经环磷酰胺（CY）预处理的C3H/He小鼠中诱导出实验性变应性睾丸炎（EAO）。在大多数经如此处理的小鼠中观察到了诸如曲细精管生精功能低下和间质轻度细胞浸润等病理变化。在这些小鼠中检测到了针对睾丸抗原的迟发型足垫反应（DFR）和血清中的抗精子抗体。这种睾丸炎小鼠模型新颖且简单，因为诱导过程中不使用佐剂，可用于进一步研究EAO的诱导和维持机制。
