Miller W, Ota D, Giacco G, Guinee V, Irimura T, Nicolson G, Cleary K
Clin Exp Metastasis. 1985 Jul-Sep;3(3):189-96. doi: 10.1007/BF01786762.
This retrospective study analysed the relationship of tumor size to regional and systemic metastasis and to survival according to stage of disease. Colon cancers (391 cases) that were treated surgically at M. D. Anderson Hospital from 1955 to 1975 were reviewed. Staging of disease was based on the Astler-Coller modification of Dukes' staging classification. The mean diameters (cm +/- s.e.m.) of Dukes' B1, B2, C2 and D tumors were 4.47 +/- 0.34 (n = 46), 6.61 +/- 0.29 (n = 147), 5.39 +/- 0.23 (n = 71) and 5.78 +/- 0.24 (n = 120), respectively. The mean diameter of Dukes' B2 tumors was significantly greater than C2 (P less than 0.001) and D (P less than 0.05) tumors. Within stage B and C, size of the primary tumor showed no relationship to five year adjusted survival. Our findings suggest that colon carcinoma metastasis and survival are independent of tumor size. Because tumor burden does not account for distant disease, specific tumor cell phenotypes and biological processes are probably more important in determining metastatic disease.
这项回顾性研究根据疾病分期分析了肿瘤大小与区域及全身转移以及生存之间的关系。对1955年至1975年在MD安德森医院接受手术治疗的391例结肠癌病例进行了回顾。疾病分期基于阿斯泰勒 - 科勒对杜克分期分类法的改良。杜克B1、B2、C2和D期肿瘤的平均直径（厘米±标准误）分别为4.47±0.34（n = 46）、6.61±0.29（n = 147）、5.39±0.23（n = 71）和5.78±0.24（n = 120）。杜克B2期肿瘤的平均直径显著大于C2期（P < 0.001）和D期（P < 0.05）肿瘤。在B期和C期内，原发肿瘤大小与五年校正生存率无关。我们的研究结果表明，结肠癌转移和生存与肿瘤大小无关。由于肿瘤负荷不能解释远处疾病，特定的肿瘤细胞表型和生物学过程在决定转移性疾病方面可能更为重要。
