El Gharib Anthony, Nassif Léa, Karam Karam, Fiani Elias
University of Balamand, Beirut, Lebanon.
J Investig Med High Impact Case Rep. 2025 Jan-Dec;13:23247096251348903. doi: 10.1177/23247096251348903. Epub 2025 Jun 19.
Systemic sclerosis (SSc) is a rare autoimmune disorder that leads to progressive fibrosis and vascular dysfunction, frequently affecting the gastrointestinal tract with around 90% of patients experiencing gastrointestinal complications, with severe manifestations such as gastric antral vascular ectasia and rectal telangiectasia which lead to chronic bleeding and iron-deficiency anemia. This review and case report explore the pathophysiology of GI involvement in SSc, emphasizing fibrosis, microvascular damage, and dysmotility. It also highlights treatment options, including endoscopic interventions like argon plasma coagulation and pharmacological therapies.
系统性硬化症（SSc）是一种罕见的自身免疫性疾病，可导致进行性纤维化和血管功能障碍，常累及胃肠道，约90%的患者会出现胃肠道并发症，严重表现如胃窦血管扩张和直肠毛细血管扩张，可导致慢性出血和缺铁性贫血。本综述和病例报告探讨了系统性硬化症中胃肠道受累的病理生理学，重点关注纤维化、微血管损伤和运动障碍。它还强调了治疗选择，包括氩等离子体凝固等内镜干预措施和药物治疗。
