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迷幻药与睡眠的交叉研究:探索对睡眠结构、梦境状态及治疗意义的影响

The Intersection of Psychedelics and Sleep: Exploring the Impacts on Sleep Architecture, Dream States, and Therapeutic Implications.

作者信息

Zhai Haojiang, Wang Hongshuang, Li Haohong, Wang Xiaohui

机构信息

Laboratory of Chemical Biology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, China.

School of Applied Chemistry and Engineering, University of Science and Technology of China, Hefei, Anhui 230026, China.

出版信息

ACS Pharmacol Transl Sci. 2025 May 15;8(6):1832-1836. doi: 10.1021/acsptsci.5c00234. eCollection 2025 Jun 13.

DOI:10.1021/acsptsci.5c00234
PMID:40534671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12171890/
Abstract

The interplay between psychedelics, such as psilocybin, lysergic acid diethylamide (LSD) and dimethyltryptamine (DMT), and sleep is an emerging area, but their impact on sleep remains relatively underexplored. This viewpoint provides a perspective on how psychedelics may alter sleep phases, dreaming, and their potential therapeutic applications for sleep disorders.

摘要

诸如裸盖菇素、麦角酸二乙酰胺(LSD)和二甲基色胺(DMT)等迷幻剂与睡眠之间的相互作用是一个新兴领域,但它们对睡眠的影响仍相对未得到充分探索。本文观点阐述了迷幻剂可能如何改变睡眠阶段、梦境以及它们对睡眠障碍的潜在治疗应用。

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本文引用的文献

1
Preliminary Evidence of Sleep Improvements Following Psilocybin Administration, and their Involvement in Antidepressant Therapeutic Action.初步证据表明,服用裸盖菇素后睡眠质量得到改善,且其可能与抗抑郁的治疗作用有关。
Curr Psychiatry Rep. 2024 Nov;26(11):659-669. doi: 10.1007/s11920-024-01539-8. Epub 2024 Nov 13.
2
5-MeO-DMT induces sleep-like LFP spectral signatures in the hippocampus and prefrontal cortex of awake rats.5-MeO-DMT 在清醒大鼠的海马体和前额叶皮层中诱导出类似睡眠的 LFPs 频谱特征。
Sci Rep. 2024 May 17;14(1):11281. doi: 10.1038/s41598-024-61474-9.
3
LSD increases sleep duration the night after microdosing.LSD 会增加微剂量使用后次日的睡眠时间。
Transl Psychiatry. 2024 Apr 15;14(1):191. doi: 10.1038/s41398-024-02900-4.
4
Vivid dreams are associated with a high percentage of REM sleep: a prospective study in veterans.生动的梦境与 REM 睡眠的高比例有关:一项退伍军人的前瞻性研究。
J Clin Sleep Med. 2023 Sep 1;19(9):1661-1668. doi: 10.5664/jcsm.10642.
5
Converging theories on dreaming: Between Freud, predictive processing, and psychedelic research.关于梦境的趋同理论:介于弗洛伊德、预测加工和迷幻剂研究之间
Front Hum Neurosci. 2023 Feb 16;17:1080177. doi: 10.3389/fnhum.2023.1080177. eCollection 2023.
6
Efficacy and tolerability of pharmacological treatments for insomnia in adults: A systematic review and network meta-analysis.成人失眠症药物治疗的疗效与耐受性:一项系统评价与网状Meta分析
Sleep Med Rev. 2023 Apr;68:101746. doi: 10.1016/j.smrv.2023.101746. Epub 2023 Jan 14.
7
The neural basis of psychedelic action.迷幻剂作用的神经基础。
Nat Neurosci. 2022 Nov;25(11):1407-1419. doi: 10.1038/s41593-022-01177-4. Epub 2022 Oct 24.
8
Default Mode Network Modulation by Psychedelics: A Systematic Review.迷幻剂对默认模式网络的调制:系统综述。
Int J Neuropsychopharmacol. 2023 Mar 22;26(3):155-188. doi: 10.1093/ijnp/pyac074.
9
Phenomenology and content of the inhaled N, N-dimethyltryptamine (N, N-DMT) experience.吸入 N, N-二甲基色胺(N, N-DMT)体验的现象学和内容。
Sci Rep. 2022 May 24;12(1):8562. doi: 10.1038/s41598-022-11999-8.
10
Psilocin acutely alters sleep-wake architecture and cortical brain activity in laboratory mice.裸盖菇素在急性给药时会改变实验小鼠的睡眠-觉醒结构和大脑皮层活动。
Transl Psychiatry. 2022 Feb 23;12(1):77. doi: 10.1038/s41398-022-01846-9.