Faculty of Engineering, University of Auckland, Auckland, 1010, New Zealand.
School of Pharmacy, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Grafton, Auckland, 1023, New Zealand.
Transl Psychiatry. 2024 Apr 15;14(1):191. doi: 10.1038/s41398-024-02900-4.
Microdosing psychedelic drugs at a level below the threshold to induce hallucinations is an increasingly common lifestyle practice. However, the effects of microdosing on sleep have not been previously reported. Here, we report results from a Phase 1 randomized controlled trial in which 80 healthy adult male volunteers received a 6-week course of either LSD (10 µg) or placebo with doses self-administered every third day. Participants used a commercially available sleep/activity tracker for the duration of the trial. Data from 3231 nights of sleep showed that on the night after microdosing, participants in the LSD group slept an extra 24.3 min per night (95% Confidence Interval 10.3-38.3 min) compared to placebo-with no reductions of sleep observed on the dosing day itself. There were no changes in the proportion of time spent in various sleep stages or in participant physical activity. These results show a clear modification of the physiological sleep requirements in healthy male volunteers who microdose LSD. The clear, clinically significant changes in objective measurements of sleep observed are difficult to explain as a placebo effect. Trial registration: Australian New Zealand Clinical Trials Registry: A randomized, double-blind, placebo-controlled trial of repeated microdoses of lysergic acid diethylamide (LSD) in healthy volunteers; https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381476 ; ACTRN12621000436875.
低剂量摄入致幻药物（低于引起幻觉的阈值）作为一种生活方式，正变得越来越流行。然而，低剂量摄入对睡眠的影响尚未被报道。在此，我们报告了一项 1 期随机对照试验的结果，80 名健康成年男性志愿者接受了为期 6 周的 LSD（10μg）或安慰剂治疗，每隔三天自行给药。参与者在整个试验期间使用了一款商业可用的睡眠/活动追踪器。来自 3231 个夜晚的睡眠数据显示，在低剂量摄入后的当晚，LSD 组的参与者每晚额外多睡 24.3 分钟（95%置信区间为 10.3-38.3 分钟），而在给药当天本身并没有观察到睡眠时间的减少。各种睡眠阶段的时间比例或参与者的身体活动没有变化。这些结果表明，在低剂量摄入 LSD 的健康男性志愿者中，生理睡眠需求明显改变。对睡眠的客观测量观察到的明显、具有临床意义的变化，很难用安慰剂效应来解释。试验注册：澳大利亚新西兰临床试验注册中心：在健康志愿者中重复低剂量麦角酸二乙酰胺（LSD）的随机、双盲、安慰剂对照试验；https://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=381476 ；ACTRN12621000436875。
