Li Hui, Ren Yuwei, Zhan Ying, Yu Xiaoyu, Zhang Xin, Chen Hongzhou, Li Qi, Cheng Jianghua, Ye Yingwang
School of Food and Biological Engineering, Key Laboratory for Animal Food Green Manufacturing and Resource Mining of Anhui Province, Engineering Research Center of Bio-Process, Ministry of Education, Hefei University of Technology, Hefei, 230009, China.
Institute of Agro-Products Processing, Anhui Academy of Agricultural Sciences, Anhui Engineering Laboratory of Food Microbial Fermentation and Functional Application, Hefei, 230036, China.
Mater Today Bio. 2025 Jun 6;33:101953. doi: 10.1016/j.mtbio.2025.101953. eCollection 2025 Aug.
Bacterial infections, especially those caused by antibiotic-resistant (), hinder the healing of scalds in food processing environments. This study developed a high-entropy nanozyme (HEzyme) hydrogel system that exhibited efficient reactive oxygen species (ROS) and photothermal antibacterial effects. The HEzyme was synthesized using a carbon-oxygen-silicon framework-assisted method, incorporating multiple metal species (CoNiCuZnCe). It demonstrated superior catalytic efficiency, generating hydroxyl radicals (•OH) from hydrogen peroxide (HO). Exposure to 808 nm irradiation caused a rapid temperature increase, enabling photothermal effect. HEzyme was integrated into a chitosan-based hydrogel microneedle system, which generated ROS and heat when exposed to HO and irradiation. The microneedles, designed for transdermal use, enhanced wound healing and minimized inflammation. In vitro and in vivo tests confirmed that the microneedles effectively eradicated and accelerated tissue healing. This approach offers a promising solution for treating antibiotic-resistant infections and promoting healing in scald wounds.
细菌感染，尤其是由耐抗生素（）引起的感染，会阻碍食品加工环境中烫伤的愈合。本研究开发了一种高熵纳米酶（HEzyme）水凝胶系统，该系统具有高效的活性氧（ROS）和光热抗菌作用。采用碳-氧-硅框架辅助法合成了包含多种金属物种（CoNiCuZnCe）的HEzyme。它表现出优异的催化效率，能将过氧化氢（HO）转化为羟基自由基（•OH）。暴露于808nm照射下会导致温度迅速升高，从而产生光热效应。将HEzyme整合到基于壳聚糖的水凝胶微针系统中，该系统在暴露于HO和照射时会产生活性氧和热量。设计用于经皮使用的微针可促进伤口愈合并将炎症降至最低。体外和体内测试证实，微针能有效根除（此处原文缺失相关内容）并加速组织愈合。这种方法为治疗耐抗生素感染和促进烫伤伤口愈合提供了一种有前景的解决方案。
