Duan Hua, Cheng Mengqi, Sun Qianhui, Chen Cihui
Department of Oncology, The First Affiliated Hospital of Zhejiang Chinese Medical University (Zhejiang Provincial Hospital of Chinese Medicine), Hangzhou, China.
Cancer Institute of Integrated Traditional Chinese & Western Medicine Zhejiang Chinese Medical University, Hangzhou, China.
Front Oncol. 2025 Jun 4;15:1515476. doi: 10.3389/fonc.2025.1515476. eCollection 2025.
Peritoneal malignancies (PM) represent a group of highly heterogeneous tumors associated with poor prognosis and limited effective treatment options. Recent studies have demonstrated significant progress in understanding the tumor microenvironment (TME) of PM. However, no bibliometric analysis focusing on PM and TME has been conducted. This study aims to provide a comprehensive assessment of the current research landscape and to identify key areas of interest and emerging trends in this field from a bibliometric perspective.
Publications related to the TME in PM from 2010 to 2024 were retrieved from the Web of Science Core Collection database. Microsoft Excel, VOSviewer, CiteSpace, and R package "bibliometrix" were used to perform the visualization analysis.
A total of 862 papers from 56 countries were included. Both annual publication counts and citations have increased steadily over time. The United States of America (USA) contributed the highest number of publications and demonstrated the greatest impact, followed by China and Japan. The University of Texas MD Anderson Cancer Center, Sichuan University and Fudan University were identified as the leading research institutions. Four of the top five most prolific authors are from Japan, including Kajiyama Hiroaki, Yashiro Masakazu, Fushida Sachio and Kinoshita Jun. published the largest number of articles, with 56 publications, while was the most frequently co-cited journal. Reference and keyword burst detection revealed that research hotspots include cytoreductive surgery, hyperthermic intraperitoneal chemotherapy, immunotherapy, tumor-associated macrophages, cancer-associated fibroblast and endothelial growth factor.
This study summarizes recent research frontiers and hotspots regarding the TME in PM and provided valuable references for future investigations. Immunotherapy targeting the TME is likely to become a major research direction.
腹膜恶性肿瘤（PM）是一组高度异质性的肿瘤，预后较差且有效治疗选择有限。最近的研究表明，在理解PM的肿瘤微环境（TME）方面取得了重大进展。然而，尚未对聚焦于PM和TME的文献计量学分析进行过。本研究旨在从文献计量学角度对当前的研究状况进行全面评估，并确定该领域的关键关注领域和新出现的趋势。
从Web of Science核心合集数据库中检索2010年至2024年与PM中的TME相关的出版物。使用Microsoft Excel、VOSviewer、CiteSpace和R包“bibliometrix”进行可视化分析。
共纳入来自56个国家的862篇论文。年度发表量和被引次数均随时间稳步增加。美国的出版物数量最多且影响力最大，其次是中国和日本。德克萨斯大学MD安德森癌症中心、四川大学和复旦大学被确定为领先的研究机构。前五名高产作者中有四位来自日本，包括 Kajiyama Hiroaki、Yashiro Masakazu、Fushida Sachio和Kinoshita Jun。发表的文章数量最多，有56篇，而 是被共同引用频率最高的期刊。参考文献和关键词突现检测显示，研究热点包括细胞减灭术、腹腔内热化疗、免疫疗法、肿瘤相关巨噬细胞、癌症相关成纤维细胞和血管内皮生长因子。
本研究总结了近期关于PM中TME的研究前沿和热点，并为未来的研究提供了有价值的参考。针对TME的免疫疗法可能会成为一个主要的研究方向。
