Chair and Department of Toxicology, Faculty of Pharmacy, Medical University of Lublin, Jaczewskiego 8b Street, 20-090 Lublin, Poland.
Int J Mol Sci. 2023 Mar 30;24(7):6518. doi: 10.3390/ijms24076518.
Alzheimer's disease is one of the most commonly diagnosed cases of senile dementia in the world. It is an incurable process, most often leading to death. This disease is multifactorial, and one factor of this is inflammation. Numerous mediators secreted by inflammatory cells can cause neuronal degeneration. Neuritis may coexist with other mechanisms of Alzheimer's disease, contributing to disease progression, and may also directly underlie AD. Although much has been established about the inflammatory processes in the pathogenesis of AD, many aspects remain unexplained. The work is devoted in particular to the pathomechanism of inflammation and its role in diagnosis and treatment. An in-depth and detailed understanding of the pathomechanism of neuroinflammation in Alzheimer's disease may help in the development of diagnostic methods for early diagnosis and may contribute to the development of new therapeutic strategies for the disease.
阿尔茨海默病是世界上最常见的老年痴呆症诊断病例之一。它是一种不可治愈的过程，最常见的导致死亡。这种疾病是多因素的，其中一个因素是炎症。炎症细胞分泌的许多介质可导致神经元变性。神经炎可能与阿尔茨海默病的其他机制共存，促进疾病进展，也可能直接导致 AD。尽管已经确定了 AD 发病机制中的炎症过程，但仍有许多方面尚未得到解释。这项工作特别致力于炎症的发病机制及其在诊断和治疗中的作用。深入详细地了解阿尔茨海默病中的神经炎症发病机制可能有助于开发早期诊断的诊断方法，并可能有助于开发针对该疾病的新治疗策略。
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