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成人隐匿性自身免疫性糖尿病:老年患者的诊断挑战

Latent Autoimmune Diabetes in Adults: A Diagnostic Challenge in Elderly Patients.

作者信息

Monteiro Filipa, Artilheiro Catarina, Shara Tetiana, Andrade Maria Teresa, Santos Leticia, Nunes Andreia, Ramalho Sara, Escarigo Conceição

机构信息

Internal Medicine, Garcia de Orta Hospital, Almada, PRT.

出版信息

Cureus. 2025 May 20;17(5):e84457. doi: 10.7759/cureus.84457. eCollection 2025 May.

DOI:10.7759/cureus.84457
PMID:40539164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12177819/
Abstract

Diabetes mellitus (DM) is a chronic condition with several subtypes that differ in etiology and clinical progression. Type 2 diabetes (T2DM) is the most commonly diagnosed form and is closely linked to obesity and physical inactivity, while type 1 diabetes (T1DM) is largely autoimmune in origin. A less understood subtype, latent autoimmune diabetes in adults (LADA), shares characteristics of both T2DM and T1DM and is often misdiagnosed as T2DM. This article presents three clinical cases of elderly patients misdiagnosed with T2DM, but who actually had LADA, highlighting the challenges associated with its early identification and the importance of more accurate diagnostic approaches.

摘要

糖尿病(DM)是一种慢性疾病,有几种亚型,其病因和临床进展各不相同。2型糖尿病(T2DM)是最常见的诊断形式,与肥胖和缺乏身体活动密切相关,而1型糖尿病(T1DM)在很大程度上起源于自身免疫。一种了解较少的亚型,成人隐匿性自身免疫性糖尿病(LADA),兼具T2DM和T1DM的特征,常被误诊为T2DM。本文介绍了三例老年患者被误诊为T2DM但实际患有LADA的临床病例,突出了早期识别LADA的挑战以及更准确诊断方法的重要性。

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本文引用的文献

1
Latent Autoimmune Diabetes in Adults: A Case Report.成人隐匿性自身免疫性糖尿病:一例报告
Oman Med J. 2024 Jan 31;39(1):e596. doi: 10.5001/omj.2024.05. eCollection 2024 Jan.
2
A Review on Latent Autoimmune Diabetes in Adults.成人隐匿性自身免疫性糖尿病综述
Cureus. 2023 Oct 29;15(10):e47915. doi: 10.7759/cureus.47915. eCollection 2023 Oct.
3
Diagnostic camouflage: A case report on Latent autoimmune diabetics of adulthood.诊断伪装:一例成年隐匿性自身免疫性糖尿病病例报告
Ann Med Surg (Lond). 2022 Sep 14;82:104699. doi: 10.1016/j.amsu.2022.104699. eCollection 2022 Oct.
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A Case of Late Diagnosis of Latent Autoimmune Diabetes in Adults.一例成人隐匿性自身免疫性糖尿病的延迟诊断病例
Cureus. 2022 Feb 2;14(2):e21826. doi: 10.7759/cureus.21826. eCollection 2022 Feb.
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Etiology and Pathogenesis of Latent Autoimmune Diabetes in Adults (LADA) Compared to Type 2 Diabetes.成人隐匿性自身免疫性糖尿病(LADA)与2型糖尿病相比的病因及发病机制
Front Physiol. 2019 Mar 26;10:320. doi: 10.3389/fphys.2019.00320. eCollection 2019.
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Recognizing and Appropriately Treating Latent Autoimmune Diabetes in Adults.识别并妥善治疗成人隐匿性自身免疫性糖尿病。
Diabetes Spectr. 2016 Nov;29(4):249-252. doi: 10.2337/ds15-0047.
7
Challenges of LADA Diagnosis and Treatment: Lessons From 2 Case Reports.成人隐匿性自身免疫性糖尿病的诊断与治疗挑战:来自2例病例报告的经验教训
Am J Ther. 2016 Sep-Oct;23(5):e1270-4. doi: 10.1097/MJT.0000000000000349.
8
Insulin secretion in patients with latent autoimmune diabetes (LADA): half way between type 1 and type 2 diabetes: action LADA 9.成人隐匿性自身免疫性糖尿病(LADA)患者的胰岛素分泌:介于1型和2型糖尿病之间:LADA 9研究
BMC Endocr Disord. 2015 Jan 9;15:1. doi: 10.1186/1472-6823-15-1.
9
Adult-onset autoimmune diabetes in Europe is prevalent with a broad clinical phenotype: Action LADA 7.欧洲成人起病自身免疫性糖尿病患病率高,临床表现谱广泛:LADA7 行动。
Diabetes Care. 2013 Apr;36(4):908-13. doi: 10.2337/dc12-0931. Epub 2012 Dec 17.