糖尿病患者血清白蛋白水平与深静脉血栓形成风险的关联：一项回顾性病例对照研究。

Association between serum albumin levels and risk of deep vein thrombosis in diabetic patients: a retrospective case-control study.

作者信息

Cao Yanli, Li Yang, Zhang Wenxiu, Lei Chen

机构信息

The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.

Department of Geriatrics and Special Needs, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, 750004, China.

出版信息

Hormones (Athens). 2025 Jun 20. doi: 10.1007/s42000-025-00679-7.

DOI:10.1007/s42000-025-00679-7

PMID:40540240

Abstract

PURPOSE

This study aimed to evaluate the predictive value of serum albumin (ALB) levels for deep vein thrombosis (DVT) in diabetic patients, providing a simple and effective biomarker for the early identification of high-risk DVT patients.

METHODS

A retrospective case-control study was conducted in 133 diabetic patients hospitalized at our hospital between January 2020 and January 2023, including 55 patients diagnosed with DVT (observation group) and 78 patients without DVT (control group). Clinical data, including demographic characteristics, comorbidities, and laboratory indicators (such as serum ALB, HbA1c, HDL, LDL, cardiovascular disease (CVD) history, and insulin treatment) were collected from medical records. Logistic regression analysis was used to identify independent predictors of DVT, adjusting for potential confounding factors, including body mass index (BMI), smoking history, and platelet count. Additionally, the diagnostic performance of serum ALB was assessed using ROC curve analysis in the overall cohort and stratified by CVD status, insulin treatment, and ALB levels.

RESULTS

Serum ALB levels were significantly lower in the DVT group compared to the control group (3.18 ± 0.26 vs. 3.53 ± 0.41 g/L, P < 0.001). Logistic regression confirmed serum ALB as an independent predictor of DVT (univariate OR = 0.070; multivariate OR = 0.076; both P < 0.001). ROC analysis demonstrated good diagnostic performance for serum ALB (AUC = 0.827), with higher accuracy observed in patients with CVD (AUC = 0.885) and those with hypoalbuminemia (AUC = 0.780). Additionally, serum ALB was also a strong predictor for DVT in the insulin-treated subgroup, confirming its diagnostic value across different diabetic subgroups.

CONCLUSION

Low serum ALB levels are significantly associated with the occurrence of DVT in diabetic patients. Serum ALB can serve as an effective biomarker for DVT, and regular monitoring can aid in the early identification of high-risk patients and prevent thrombosis.

摘要

目的

本研究旨在评估血清白蛋白（ALB）水平对糖尿病患者深静脉血栓形成（DVT）的预测价值，为早期识别高危DVT患者提供一种简单有效的生物标志物。

方法

对2020年1月至2023年1月在我院住院的133例糖尿病患者进行回顾性病例对照研究，其中55例诊断为DVT（观察组），78例未发生DVT（对照组）。从病历中收集临床资料，包括人口统计学特征、合并症和实验室指标（如血清ALB、糖化血红蛋白、高密度脂蛋白、低密度脂蛋白、心血管疾病（CVD）史和胰岛素治疗情况）。采用逻辑回归分析确定DVT的独立预测因素，并对潜在混杂因素进行校正，包括体重指数（BMI）、吸烟史和血小板计数。此外，在整个队列中以及按CVD状态、胰岛素治疗和ALB水平分层后，使用ROC曲线分析评估血清ALB的诊断性能。

结果

DVT组血清ALB水平显著低于对照组（3.18±0.26 vs. 3.53±0.41 g/L，P<0.001）。逻辑回归证实血清ALB是DVT的独立预测因素（单因素OR=0.070；多因素OR=0.076；均P<0.001）。ROC分析显示血清ALB具有良好的诊断性能（AUC=0.827），在CVD患者（AUC=0.885）和低白蛋白血症患者（AUC=0.780）中观察到更高的准确性。此外，血清ALB也是胰岛素治疗亚组中DVT的强预测因素，证实了其在不同糖尿病亚组中的诊断价值。