Shiels M T, Czaja A J, Taswell H F, Gerin J L, Purcell R H, Ludwig J, Rakela J, Nelson C A
Gastroenterology. 1985 Dec;89(6):1230-4. doi: 10.1016/0016-5085(85)90637-7.
Of 560 hepatitis B surface antigen-positive patients who were tested for antibody to hepatitis delta-antigen by blocking radioimmunoassay, 29 (5%) were seropositive. Patients with chronic active hepatitis had a greater frequency of seropositivity than those with chronic persistent hepatitis (26% vs. 0%, p less than 0.05), and patients with symptomatic chronic disease harbored the antibody more commonly than asymptomatic counterparts (14% vs. 2%, p less than 0.01) or patients with acute hepatitis (14% vs. 1%, p less than 0.02). Of 8 patients with acute fulminant hepatitis, including 6 who died of liver failure, none were seropositive. Antibody was detected in drug users, dialysis patients, hemophiliacs, and transfusion recipients; in 17 patients, however, including 3 homosexuals, it occurred sporadically. Samples harvested in 1969 contained delta-antibody. Antibody was found in most ethnic groups, including Orientals, where it occurred only in relocated Vietnamese. We conclude that delta-antibody is detected infrequently in a diverse referral population within the United States. Seropositivity is associated with symptomatic chronic disease and histologic findings of chronic active hepatitis. Homosexuals and resettled Vietnamese are susceptible to sporadic delta-infection.
在560例通过阻断放射免疫测定法检测丁型肝炎抗原抗体的乙肝表面抗原阳性患者中，29例（5%）血清学阳性。慢性活动性肝炎患者的血清学阳性率高于慢性持续性肝炎患者（26%对0%，p<0.05），有症状的慢性疾病患者比无症状者（14%对2%，p<0.01）或急性肝炎患者（14%对1%，p<0.02）更常携带该抗体。在8例急性暴发性肝炎患者中，包括6例死于肝衰竭的患者，均无血清学阳性。在吸毒者、透析患者、血友病患者和输血接受者中检测到抗体；然而，在17例患者中，包括3例同性恋者，抗体呈散发性出现。1969年采集的样本中含有丁型抗体。在大多数种族群体中都发现了抗体，包括东方人，在东方人中仅在重新安置的越南人中出现。我们得出结论，在美国不同的转诊人群中，丁型抗体检测不常见。血清学阳性与有症状的慢性疾病和慢性活动性肝炎的组织学表现相关。同性恋者和重新安置的越南人易发生散发性丁型感染。
