乙型肝炎病毒感染中丁型抗原抗体的发生率及意义。

Incidence and significance of antibodies to delta antigen in hepatitis B virus infection.

作者信息

Rizzetto M, Shih J W, Gocke D J, Purcell R H, Verme G, Gerin J L

出版信息

Lancet. 1979 Nov 10;2(8150):986-90. doi: 10.1016/s0140-6736(79)92561-3.

Abstract

A microtitre solid-phase blocking radioimmunoassay (RIA) for antibody to the hepatitis B virus (HBV)-associated delta antigen was specific and detected anti-delta antibody at dilutions of serum of up to 10(6). Analysis of sera from HBsAg-negative subjects and different categories of HBsAg carriers from different regions confirmed the association of anti-delta antibody with HBV infection. Anti-delta antibody was detected in persistently high titres in 19.1% and 2.6% of sera from patients with chronic hepatitis and symptomatic chronic carriers, respectively, and was not detected in the sera of HBsAg-negative controls. Anti-delta antibody appeared transiently and in low titres (less than 1:500) in 4.8% of sera from patients with acute type B hepatitis. The presence and persistence of anti-delta antibody seem to be associated with chronic HBV infection and the development of progressive liver damage.

摘要

一种用于检测乙型肝炎病毒（HBV）相关δ抗原抗体的微量滴定固相阻断放射免疫分析（RIA）具有特异性，能在血清稀释至10⁶时检测到抗δ抗体。对来自不同地区的HBsAg阴性受试者及不同类别HBsAg携带者的血清分析证实了抗δ抗体与HBV感染有关。在慢性肝炎患者和有症状的慢性携带者的血清中，分别有19.1%和2.6%的血清持续检测到高滴度的抗δ抗体，而在HBsAg阴性对照血清中未检测到。在急性乙型肝炎患者的血清中，有4.8%的血清短暂出现低滴度（小于1:500）的抗δ抗体。抗δ抗体的存在和持续似乎与慢性HBV感染及进行性肝损伤的发展有关。