Bergman Lina, Zecevic Ernad, Damén Tor, Markovic Gabriela, Martinik Anna, Saarijärvi Markus, Eckerblad Jeanette, Nilsson Ulrica
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden
Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Huddinge, Sweden.
BMJ Open. 2025 Jun 22;15(6):e098208. doi: 10.1136/bmjopen-2024-098208.
Cardiovascular disease is one of the most common health issues facing the older population, and the number of older adults undergoing cardiac surgery is expected to increase. Postoperative neurocognitive impairment is a frequent and often unrecognised complication that can adversely affect a patient's recovery, quality of life and daily activities, as well as impact the lives of their family members. Patients may express cognitive difficulties as a feeling of 'not being the same since the operation'. This study aims to investigate the factors that influence neurocognitive function and patient-reported cognitive symptoms among patients aged 65 and older following cardiac surgery, and explore the impact on the overall postoperative recovery. Additionally, the study aims to describe the perspectives of close relatives on the recovery process.
A longitudinal observational study with a mixed-methods approach will be conducted in two thoracic surgical departments in Sweden. A total of 220 patients and 1 close relative for each patient will participate. Neurocognitive function will be assessed preoperatively and at 1, 3 and 6 months postoperatively using a digitalised neurocognitive test battery. We will also evaluate postoperative patient-reported cognitive symptoms and signs, delirium, frailty, health-related quality of life, depression, perceived self-efficacy, fatigue and functional capacity. Each patient's close relative will assess the observed cognitive function and report on caregiver burden. At the 6-month mark, a purposive sample of patients and their close relatives will be interviewed to explore their experiences of postoperative cognitive recovery.
The study has been approved by the Swedish Ethical Review Authority (Reference number: 2024-03380-01) and will adhere to the Helsinki Declaration and its amendments. The results will be disseminated through peer-reviewed journals and scientific conferences, as well as presented in various popular science forums and patient organisations.
NCT06469515; Pre-results.
心血管疾病是老年人群面临的最常见健康问题之一，预计接受心脏手术的老年人数量将会增加。术后神经认知障碍是一种常见且常未被识别的并发症，会对患者的康复、生活质量和日常活动产生不利影响，还会影响其家庭成员的生活。患者可能会将认知困难表述为“手术后感觉不一样了”。本研究旨在调查影响65岁及以上心脏手术后患者神经认知功能和患者报告的认知症状的因素，并探讨对术后整体康复的影响。此外，该研究旨在描述近亲对康复过程的看法。
将在瑞典的两个胸外科进行一项采用混合方法的纵向观察性研究。共有220名患者以及每位患者的1名近亲参与。术前以及术后1个月、3个月和6个月使用数字化神经认知测试组合评估神经认知功能。我们还将评估术后患者报告的认知症状和体征、谵妄、虚弱、健康相关生活质量、抑郁、自我效能感、疲劳和功能能力。每位患者的近亲将评估观察到的认知功能并报告照护负担。在6个月时，将对有目的抽样的患者及其近亲进行访谈，以探讨他们术后认知康复的经历。
该研究已获得瑞典伦理审查局批准（参考编号：2024 - 03380 - 01），并将遵循《赫尔辛基宣言》及其修正案。研究结果将通过同行评审期刊和科学会议进行传播，也会在各种科普论坛和患者组织中展示。
NCT06469515；预结果。
