Carrera-Bastos Pedro, Plaza-Florido Abel, Santos-Lozano Alejandro, Borba Vânia, Rodríguez-Romo Gabriel, García-Chico Celia, Lista Simone, Saco-Ledo Gonzalo, Emanuele Enzo, Shoenfeld Yehuda, Lucia Alejandro
Faculty of Biomedical and Health Sciences. Universidad Europea de Madrid, Madrid, Spain.
Center for Primary Health Care Research, Department of Clinical Sciences, Lund University, Malmö, Sweden.
J Transl Autoimmun. 2025 Jun 7;11:100295. doi: 10.1016/j.jtauto.2025.100295. eCollection 2025 Dec.
To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians.
We conducted data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases.
Sixteen autoimmune disease-related proteins were identified within the proteomic signatures of centenarians. Albumin was the most connected hub protein, notably elevated in centenarians compared to younger controls, suggesting a protective role. Eight of the identified autoimmunity-related proteins-ADIPOQ, C1S, C5, C7, C9, CFD, MASP1, and SERPING1-were associated with the complement system.
Elevated albumin levels and a prominent complement system presence in centenarians' blood proteome may contribute to resistance to autoimmunity, highlighting potential protective mechanisms against autoimmune diseases in extreme longevity.
鉴定与百岁老人血液中自身免疫抗性潜在相关的标志性蛋白质。
我们使用基因/蛋白质相互作用检索工具（STRING）和PHENOPEDIA数据库对先前发表的蛋白质组学结果进行数据挖掘。
在百岁老人的蛋白质组特征中鉴定出16种自身免疫性疾病相关蛋白。白蛋白是连接性最强的枢纽蛋白，与年轻对照组相比，百岁老人体内白蛋白水平显著升高，表明其具有保护作用。鉴定出的8种自身免疫相关蛋白——脂联素（ADIPOQ）、补体C1S、补体C5、补体C7、补体C9、补体因子D（CFD）、甘露聚糖结合凝集素相关丝氨酸蛋白酶1（MASP1）和补体第一抑制因子（SERPING1）——与补体系统相关。
百岁老人血液蛋白质组中白蛋白水平升高以及补体系统显著存在可能有助于抵抗自身免疫，突出了极端长寿情况下针对自身免疫性疾病的潜在保护机制。
