Biomedical Materials Engineering Research Center, Hubei Key Laboratory of Polymer Materials, Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, School of Materials Science & Engineering, State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei University, Wuhan, 430062, China.
School of Health Science & Biomedical Engineering, Hebei University of Technology, Xiping Avenue 5340#, Tianjin, 300401, China.
Small. 2024 Mar;20(9):e2306553. doi: 10.1002/smll.202306553. Epub 2023 Oct 17.
Bacteria-induced epidemics and infectious diseases are seriously threatening the health of people around the world. In addition, antibiotic therapy has been inducing increasingly more serious bacterial resistance, which makes it urgent to develop new treatment strategies to combat bacteria, including multidrug-resistant bacteria. Natural extracts displaying antibacterial activity and good biocompatibility have attracted much attention due to greater concerns about the safety of synthetic chemicals and emerging drug resistance. These antibacterial components can be isolated and utilized as antimicrobials, as well as transformed, combined, or wrapped with other substances by using modern assistive technologies to fight bacteria synergistically. This review summarizes recent advances in natural extracts from three kinds of sources-plants, animals, and microorganisms-for antibacterial applications. This work discusses the corresponding antibacterial mechanisms and the future development of natural extracts in antibacterial fields.
细菌引发的传染病正在严重威胁着全世界人民的健康。此外，抗生素疗法已经导致越来越严重的细菌耐药性，因此迫切需要开发新的治疗策略来对抗细菌，包括多药耐药菌。由于人们更加关注合成化学品的安全性和新出现的耐药性，具有抗菌活性和良好生物相容性的天然提取物引起了广泛关注。这些抗菌成分可以被分离出来并用作抗菌剂，也可以通过使用现代辅助技术与其他物质进行转化、组合或包裹，从而协同抗菌。本综述总结了植物、动物和微生物三种来源的天然提取物在抗菌应用方面的最新进展。本文讨论了相应的抗菌机制以及天然提取物在抗菌领域的未来发展。
