Gu Jiaxu, Wang Jieyi, Zhu Zimo, Lu Bingcheng, Liu Xiaoming, Yu Bo
Department of Dermatology, Peking University Shenzhen Hospital, Shenzhen, 518036, People's Republic of China.
Department of Dermatology, Shenzhen-Peking University-the Hong Kong University of Science and Technology Medical Center, Shenzhen, 518036, People's Republic of China.
Clin Cosmet Investig Dermatol. 2025 Jun 17;18:1501-1505. doi: 10.2147/CCID.S526475. eCollection 2025.
Autologous fat grafting is a widely used soft tissue filling technique for facial rejuvenation, favored for its high biocompatibility and long-lasting effects. However, the long-term risk of infection due to alterations in local tissue structure remains unclear. This article reports a case of perforating cellulitis in the frontotemporal region of a 39-year-old female patient 3 years after multiple autologous fat grafting procedures. The patient, with no significant prior medical history or immune compromise, developed sudden redness and swelling in the right temporal region, which rapidly spread to the forehead and left temporal region, resulting in perforating abscesses and fat liquefaction necrosis at the filling sites. Laboratory tests identified Staphylococcus aureus as the causative pathogen. The patient was successfully treated with intravenous ceftriaxone sodium and surgical drainage, achieving full recovery with no recurrence during a 6-month follow-up. This case highlights that repeated subcutaneous fat grafting may loosen tissue structure, potentially increasing susceptibility to infection spread. It underscores the importance of vigilance for delayed infections in patients with a history of cosmetic procedures, even years post-operation. Clinicians should consider aesthetic fillings as a possible risk factor for cellulitis and prioritize prompt pathogen identification and aggressive treatment. The findings emphasize the need for long-term monitoring and further research into infection mechanisms post-aesthetic surgery to enhance procedural safety.
自体脂肪移植是一种广泛应用于面部年轻化的软组织填充技术，因其高生物相容性和持久效果而受到青睐。然而，由于局部组织结构改变导致的长期感染风险仍不明确。本文报告了一例39岁女性患者在多次自体脂肪移植手术后3年出现额颞部穿孔性蜂窝织炎的病例。该患者既往无重大病史或免疫功能低下，右侧颞部突然出现红肿，并迅速蔓延至前额和左侧颞部，导致填充部位出现穿孔性脓肿和脂肪液化坏死。实验室检查确定金黄色葡萄球菌为致病病原体。患者通过静脉注射头孢曲松钠和手术引流成功治愈，在6个月的随访中完全康复且无复发。该病例强调，反复进行皮下脂肪移植可能会使组织结构松弛，潜在地增加感染扩散的易感性。它强调了对有美容手术史的患者，即使在术后数年，也要警惕延迟感染的重要性。临床医生应将美容填充视为蜂窝织炎的一个可能危险因素，并优先进行病原体的快速鉴定和积极治疗。这些发现强调了长期监测以及对美容手术后感染机制进行进一步研究以提高手术安全性的必要性。
