Li De-Hui, Qiao Chang, Han Yu-Tong, Ge Jian-Li
Oncology Department II, The First Affiliated Hospital of Hebei University of Chinese Medicine (Hebei Province Hospital of Chinese Medicine), Key Laboratory of Integrated Chinese and Western Medicine for Gastroenterology Research, Hebei Industrial Technology Institute for Traditional Chinese Medicine Preparation, Shijiazhuang 050000, Hebei Province, China.
Graduate School, Hebei University of Chinese Medicine, Shijiazhuang 050000, Hebei Province, China.
World J Gastrointest Oncol. 2025 Jun 15;17(6):105062. doi: 10.4251/wjgo.v17.i6.105062.
In this editorial, we comment on the article by Qin , recently published in the . Malignant tumors of the digestive tract represent a significant health threat. Kinesin family member 14 (KIF14), a critical kinesin, is pivotal in the proliferation, migration, and invasion of tumor cells. It has emerged as a focal point in recent studies of malignant tumors in the digestive tract. This article reviews the current research on KIF14 within these tumors and details its significant role in tumor cell behaviors, including proliferation, apoptosis, migration, invasion, and angiogenesis, alongside the regulatory mechanisms of the associated intracellular signaling pathways. Additionally, it explores the clinical value of KIF14 as a potential biomarker for early diagnosis, disease monitoring, and prognostic evaluation in malignant tumors of the digestive tract. The article concludes by introducing the potential regulatory role of traditional Chinese medicine, aiming to combine the strengths of both modern and traditional medical approaches to enhance treatment outcomes and prognosis for patients with these tumors.
在这篇社论中，我们对秦最近发表在《 》上的文章进行评论。消化道恶性肿瘤对健康构成重大威胁。驱动蛋白家族成员14（KIF14）作为一种关键的驱动蛋白，在肿瘤细胞的增殖、迁移和侵袭中起着关键作用。它已成为近期消化道恶性肿瘤研究的焦点。本文综述了目前在这些肿瘤中对KIF14的研究，并详细阐述了其在肿瘤细胞行为中的重要作用，包括增殖、凋亡、迁移、侵袭和血管生成，以及相关细胞内信号通路的调控机制。此外，还探讨了KIF14作为消化道恶性肿瘤早期诊断、疾病监测和预后评估潜在生物标志物的临床价值。文章最后介绍了中药的潜在调节作用，旨在结合现代医学和传统医学的优势，提高这些肿瘤患者的治疗效果和预后。
