Gong Xia, Chen Cen, Shen Jun-Fei
Department of Pediatrics, Dazu Hospital of Chongqing Medical University, Chongqing 402360, China.
World J Gastrointest Oncol. 2025 Jun 15;17(6):103632. doi: 10.4251/wjgo.v17.i6.103632.
This retrospective study aimed to define associations between () in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.
To define associations between in childhood and risk factors for gastric cancer with special emphasis on the role of family history of cancer.
Details of 600 children who were subjected to upper gastrointestinal endoscopies at our institution are analyzed. Children were classified into positive and negative groups for infection based on biopsy and rapid urease tests. The occurrences of gastric carcinoma, chronic superficial gastritis, glandular atrophy, and intestinal metaplasia among the groups are compared.
In our study, among the overall population, 330 children tested positive for , which constituted 55% of the study population. The group denoting positivity was found to have strikingly higher frequencies of chronic superficial gastritis (78.8% 5.9%), gastric atrophy (39.4% 7%), and intestinal metaplasia (0.9% 0%), as compared to the -negative group. It is interesting to observe that there were a few but statistically significant cases of -positive children having a family history of gastric cancer (1.2%), whereas no such cases were reported in children who were -negative.
Our study finds that infection in childhood is associated with an increased risk of precancerous gastric conditions and that family history might provide an additional risk. These insights recommend the necessity of early detection and intervention and management strategies in childhood, especially in those families with histories of gastric cancer.
这项回顾性研究旨在确定儿童时期（）与胃癌风险因素之间的关联，特别强调癌症家族史的作用。
确定儿童时期（）与胃癌风险因素之间的关联，特别强调癌症家族史的作用。
分析了在我们机构接受上消化道内镜检查的600名儿童的详细情况。根据活检和快速尿素酶试验，将儿童分为幽门螺杆菌感染阳性和阴性组。比较两组中胃癌、慢性浅表性胃炎、腺体萎缩和肠化生的发生率。
在我们的研究中，在总体人群中，330名儿童幽门螺杆菌检测呈阳性，占研究人群的55%。与幽门螺杆菌阴性组相比，幽门螺杆菌阳性组的慢性浅表性胃炎（78.8%±5.9%）、胃萎缩（39.4%±7%）和肠化生（0.9%±0%）的发生率明显更高。有趣的是，观察到有少数幽门螺杆菌阳性儿童有胃癌家族史（1.2%），但具有统计学意义，而幽门螺杆菌阴性儿童中未报告此类病例。
我们的研究发现，儿童时期幽门螺杆菌感染与胃癌前期状况的风险增加有关，并且家族史可能会增加额外风险。这些见解表明有必要在儿童时期，特别是在有胃癌家族史的家庭中，尽早进行幽门螺杆菌检测以及采取干预和管理策略。
