de Bruijn Linske, van Duijne Henriëtte M, Vermeulen Roel C H, Vlaanderen Jelle J, Kromhout Hans, Jóźwiak Katarzyna, van Leeuwen Flora E, Berentzen Nina E, Schaapveld Michael
Netherlands Cancer Institute, Amsterdam, Netherlands.
Utrecht University, Utrecht, Utrecht, Netherlands.
Cancer Epidemiol Biomarkers Prev. 2025 Jun 23. doi: 10.1158/1055-9965.EPI-25-0301.
Night shift work may be a risk factor for melanoma, potentially due to suppressed melatonin and decreased vitamin D levels. We examine the potential association between night shift work and melanoma risk using detailed, lifetime information on night shift work in a large cohort of Dutch nurses.
We used questionnaire data from the Nightingale Study obtained from 59,384 (former) female nurses aged 19-65 (median: 48.7 years; interquartile range: 39.6-55.3). Hazard ratios (HR) and 95% confidence intervals (95%CI) for melanoma risk in relation to various lifetime night shift work exposure variables were estimated.
During 10 years of follow-up, 307 women developed melanoma. Melanoma risk did not differ between women who worked night shifts and those who never worked night shifts (age-adjusted HR=0.98; 95%CI=0.73-1.30). No statistically significantly increased risks were found for a longer night shift work duration, a higher cumulative number of nights worked, a higher number of consecutive nights worked per month, or a shorter time since quitting night shift work.
We found no association between night shift work exposure and melanoma risk.
This study should reassure nurses that working night shifts is not associated with an increased risk of melanoma.
夜班工作可能是黑色素瘤的一个风险因素，这可能是由于褪黑素分泌受抑制和维生素D水平降低所致。我们利用一大群荷兰护士关于夜班工作的详细终生信息，研究夜班工作与黑色素瘤风险之间的潜在关联。
我们使用了从59384名年龄在19 - 65岁（中位数：48.7岁；四分位间距：39.6 - 55.3）的（前）女性护士中获得的夜莺研究问卷数据。估计了与各种终生夜班工作暴露变量相关的黑色素瘤风险的风险比（HR）和95%置信区间（95%CI）。
在10年的随访期间，307名女性患黑色素瘤。夜班工作的女性与从未上过夜班的女性之间的黑色素瘤风险没有差异（年龄调整后的HR = 0.98；95%CI = 0.73 - 1.30）。对于更长的夜班工作时长、更高的累计夜班工作天数、每月连续夜班工作天数更多或自停止夜班工作以来的时间更短，均未发现有统计学上显著增加的风险。
我们发现夜班工作暴露与黑色素瘤风险之间没有关联。
这项研究应能让护士放心，夜班工作与黑色素瘤风险增加无关。
