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用于成像177Lu放射性污染的全向旋转康普顿相机的研制。

Development of an omnidirectional rotating Compton camera for imaging 177Lu radioactive contamination.

作者信息

Tsukamoto Hikari, Muraishi Hiroshi, Enomoto Ryoji, Katagiri Hideaki, Kagaya Mika, Watanabe Takara, Mizoguchi Takahiro, Fukumoto Masaya, Kano Daisuke, Watanabe Yusuke, Sakaguchi Kazuya, Ishiyama Hiromichi

机构信息

School of Allied Health Sciences, Kitasato University, Sagamihara, Kanagawa, Japan.

Department of Radiological Technology, Tokai University Hospital, Isehara, Kanagawa, Japan.

出版信息

PLoS One. 2025 Jun 23;20(6):e0325586. doi: 10.1371/journal.pone.0325586. eCollection 2025.

Abstract

In this study, we developed an omnidirectional rotating Compton camera that was capable of imaging low-level radioactive contamination caused by 177Lu-oxodotreotide, a novel radiopharmaceutical that has recently been attracting attention in nuclear medicine. The detector employs a compact design that comprises only six scintillator crystals mounted on a motorized rotating stage. By optimizing the crystal type and size, and optimizing the interval between crystals, the detector is able to adapt to a wide range of environmental conditions, including observable gamma-ray energies, dose rates, and angular resolution. Monte Carlo simulations using Geant4 were conducted to optimize the configuration of the detector. Based on the results of the simulation, a prototype detector using six 3.5 cm cubic [Formula: see text] crystals was developed for visualizing 177Lu-contaminated sites. The experimental results demonstrated that the detector could successfully visualize an unsealed 177Lu -oxodotreotide source with high sensitivity without being affected by gamma rays from 99TC, which is also present in nuclear medicine facilities. The developed rotating Compton camera technology is anticipated to serve as a reliable environmental monitoring tool in nuclear medicine facilities. Through its ability to rapidly detect radioactive contamination, this detector has the potential to reduce the radiation exposure risks for both medical professionals and the general public.

摘要

在本研究中,我们开发了一种全向旋转康普顿相机,它能够对由177Lu-奥曲肽引起的低水平放射性污染进行成像,177Lu-奥曲肽是一种新型放射性药物,最近在核医学领域备受关注。该探测器采用紧凑设计,仅由安装在电动旋转平台上的六个闪烁晶体组成。通过优化晶体类型和尺寸,以及优化晶体之间的间隔,该探测器能够适应广泛的环境条件,包括可观测的伽马射线能量、剂量率和角分辨率。使用Geant4进行了蒙特卡罗模拟,以优化探测器的配置。基于模拟结果,开发了一种使用六个3.5厘米立方体[公式:见正文]晶体的原型探测器,用于可视化177Lu污染的部位。实验结果表明,该探测器能够成功地以高灵敏度可视化未密封的177Lu-奥曲肽源,而不受核医学设施中也存在的99TC发出的伽马射线的影响。预计所开发的旋转康普顿相机技术将成为核医学设施中可靠的环境监测工具。通过其快速检测放射性污染的能力,该探测器有可能降低医疗专业人员和公众的辐射暴露风险。

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