An Caiyan, Zhang Kejin, Yang Xiaoguang, Fan Dongsheng, Ji Renhui, Yang Liuyi, Tong Xin, Jia Longlong, Wang Yanfang, Zhang Junjing
Department of Allergy and General Surgery, Foundational and Translational Medical Research Center, Hohhot First Hospital, Hohhot, China.
Department of Biological Sciences, College of Life Science, Institute of Population and Health, Northwest University, Xi'an, China.
Medicine (Baltimore). 2025 Jun 20;104(25):e42794. doi: 10.1097/MD.0000000000042794.
A clinical survey on 909 patients with SARS-CoV-2 subvariant BF.7 infection was conducted in Hohhot First Hospital in Hohhot, China, from October 3 to October 22, 2022. Medical records of patients were reviewed by 2 physicians, respectively. The majority of cases (over 80%) showed mild symptoms, while 25% had a history of chronic medical illness or comorbidities, including cardiovascular and cerebrovascular diseases (14%), metabolic disease (7%), obesity (4%) and others. Common symptoms of BF.7 infection included cough (70%), sore throat (53%), expectoration (51%), and fever (41%). Around 75% of patients were discharged within 2 weeks of noninvasive mechanical ventilation and traditional Chinese medicine treatment. This study also resulted in that vaccination was ineffective against BF.7 virus infection, while elderly patients with incomplete COVID-19 vaccination and preexisting chronic diseases were at higher risk for moderate or severe BF.7 infection. In conclusion, this study analyzed clinical characteristics of patients infected by BF.7 virus, emphasizing the imperative to further explore effective vaccine and develop novel prevention and treatment strategies to cope with such a continuously mutating and evolving RNA virus infection and to minimize its threat and impact on human health, especially for vulnerable population.
2022年10月3日至10月22日，中国呼和浩特市第一医院对909例感染新型冠状病毒变异株BF.7的患者进行了一项临床调查。患者的病历分别由两名医生进行审查。大多数病例（超过80%）症状较轻，而25%的患者有慢性病史或合并症，包括心血管和脑血管疾病（14%）、代谢性疾病（7%）、肥胖症（4%）等。BF.7感染的常见症状包括咳嗽（70%）、咽痛（53%）、咳痰（51%）和发热（41%）。约75%的患者在无创机械通气和中医治疗2周内出院。该研究还得出结论，疫苗接种对BF.7病毒感染无效，而未完成新冠疫苗接种且患有慢性病的老年患者感染BF.7后出现中度或重度症状的风险更高。总之，本研究分析了BF.7病毒感染患者的临床特征，强调必须进一步探索有效的疫苗，制定新的预防和治疗策略，以应对这种不断变异和进化的RNA病毒感染，并尽量减少其对人类健康，特别是对弱势群体的威胁和影响。
