Shah P M
Infection. 1985;13 Suppl 1:S34-6. doi: 10.1007/BF01644215.
Staphylococcus aureus strains were exposed in vitro to continuously decreasing cefotaxime concentrations. The initial concentration was approximately 4 X MIC and decreased at t1/2 = 60 min. A reduction in the colony count was seen even after the concentration had dropped below the MIC level. Sixteen patients with blood cultures positive for S. aureus were treated with cefotaxime. Four patient died of underlying diseases. The condition of one patient with staphylococcal endocarditis under treatment with vancomycin in combination with cefotaxime deteriorated when cefotaxime was discontinued, suggesting possible synergism between these two drugs against staphylococci.
金黄色葡萄球菌菌株在体外暴露于不断降低的头孢噻肟浓度下。初始浓度约为4倍最低抑菌浓度（MIC），并以t1/2 = 60分钟的速度下降。即使在浓度降至最低抑菌浓度水平以下后，菌落计数仍有减少。16例血培养金黄色葡萄球菌阳性的患者接受了头孢噻肟治疗。4例患者死于基础疾病。1例正在接受万古霉素联合头孢噻肟治疗的葡萄球菌性心内膜炎患者，在停用头孢噻肟后病情恶化，提示这两种药物对葡萄球菌可能存在协同作用。
