磷霉素治疗耐甲氧西林金黄色葡萄球菌败血症的体内外研究
In vitro and in vivo study of fosfomycin in methicillin-resistant Staphylococcus aureus septicaemia.
作者信息
Lau W Y, Teoh-Chan C H, Fan S T, Lau K F
出版信息
J Hyg (Lond). 1986 Jun;96(3):419-23. doi: 10.1017/s0022172400066183.
Abstract
Five hundred strains of methicillin-resistant Staphylococcus aureus were tested against various anti-staphylococcal agents. Vancomycin, fusidic acid and fosfomycin were found to be the most effective. Only 1 strain out of 500 was resistant to fosfomycin. Three patients with methicillin-resistant Staphylococcus aureus septicaemia were successfully treated by fosfomycin. We conclude that fosfomycin could be the drug of choice for methicillin-resistant Staphylococcus aureus infection.
摘要
对500株耐甲氧西林金黄色葡萄球菌进行了多种抗葡萄球菌药物的测试。发现万古霉素、夫西地酸和磷霉素最为有效。500株中只有1株对磷霉素耐药。3例耐甲氧西林金黄色葡萄球菌败血症患者用磷霉素成功治愈。我们得出结论，磷霉素可能是耐甲氧西林金黄色葡萄球菌感染的首选药物。
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