Norden C W, Niederreiter K, Shinners E M
Infection. 1986 May-Jun;14(3):136-8. doi: 10.1007/BF01643479.
Teicoplanin was used alone in the treatment of experimental osteomyelitis due to Staphylococcus aureus in rabbits. Treatment with 60 mg of teicoplanin/kg of body weight twice a day for 28 days failed to sterilize any infected rabbit bones. A possible explanation for the failure of teicoplanin may be that its in vitro activity against the infecting strain of S. aureus was substantially less under anaerobic conditions (at partial pressures of oxygen analogous to those in osteomyelitic rabbit bones) than under aerobic conditions.
替考拉宁单独用于治疗兔金黄色葡萄球菌性实验性骨髓炎。以60毫克替考拉宁/千克体重每天两次治疗28天，未能使任何受感染的兔骨灭菌。替考拉宁治疗失败的一个可能解释是，在厌氧条件下（在类似于骨髓炎兔骨中的氧分压下），其对感染的金黄色葡萄球菌菌株的体外活性比在需氧条件下显著降低。
