Powell Victoria, Meilak Emma, Booth Chloe, Owen Lucy, Brookes-Howell Lucy, Thapar Anita, Rice Frances
Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, Wales, UK
Wolfson Centre for Young People's Mental Health, Cardiff University, Cardiff, Wales, UK.
BMJ Ment Health. 2025 Jun 22;28(1):e301279. doi: 10.1136/bmjment-2024-301279.
While patient and public involvement (PPI) in research is growing, PPI in the setting of research priorities at an early stage of the research process has been limited to date. Where research priorities have been assessed, this has been done by working with members of the general public. Research priorities are likely to vary between different groups, and families affected by depression have been recognised as an important group for research.
We aimed to explore the mental health research priorities of parents with a history of depression and their children.
Data came from the Early Prediction of Adolescent Depression (EPAD) study-a UK longitudinal cohort study of parents with a history of depression and their children. During interviews, parents (n=161) and their young adult children (n=131) were asked open-ended questions about their research priorities. Responses were analysed using qualitative content analysis.
Parents and their young adult children highlighted the following research priority categories: treatment and intervention, including prevention and early intervention, public understanding of mental health, environmental or social factors that might contribute to poor mental health, the role of genetics in intergenerational transmission, and a developmental and intergenerational approach to research.
While prior research has identified the importance of intervention and social factors, our study also identified public understanding of mental health and aetiological research, particularly on the contribution of genetics relative to environmental factors, as priorities for parents with depression and their children.
Findings highlight the value of involving diverse groups in priority-setting exercises, including groups that are recognised as important for research, to allow their views to be incorporated into agenda-setting initiatives, including for research funding.
虽然患者及公众参与（PPI）研究的情况日益增多，但在研究过程早期确定研究重点方面的患者及公众参与，迄今为止仍很有限。在评估研究重点时，一直是与普通公众成员合作进行的。不同群体的研究重点可能有所不同，而受抑郁症影响的家庭已被视为重要的研究群体。
我们旨在探讨有抑郁症病史的父母及其子女的心理健康研究重点。
数据来自青少年抑郁症早期预测（EPAD）研究——一项针对有抑郁症病史的父母及其子女的英国纵向队列研究。在访谈中，向父母（n = 161）及其成年子女（n = 131）询问了关于他们研究重点的开放式问题。使用定性内容分析法对回答进行分析。
父母及其成年子女强调了以下研究重点类别：治疗与干预，包括预防和早期干预；公众对心理健康的理解；可能导致心理健康不佳的环境或社会因素；遗传学在代际传播中的作用；以及研究的发展和代际方法。
虽然先前的研究已经确定了干预和社会因素的重要性，但我们的研究还确定，公众对心理健康和病因学研究的理解，特别是关于遗传学相对于环境因素的作用，是抑郁症患者父母及其子女的研究重点。
研究结果凸显了让不同群体参与优先级设定活动的价值，包括那些被认为对研究很重要的群体，以便将他们的观点纳入议程设定举措，包括研究资金方面的举措。
