Departments of Psychiatry and Medical Genetics, University of British Columbia, Vancouver, British Columbia V5Z 4H4, Canada.
BC Mental Health and Substance Use Services Research Institute, Vancouver, British Columbia V6Z 2A9, Canada.
Cold Spring Harb Perspect Med. 2020 Jun 1;10(6):a036608. doi: 10.1101/cshperspect.a036608.
Psychiatric disorders, such as schizophrenia, depression, anxiety, and bipolar disorder, are common conditions that arise as a result of complex and heterogeneous combinations of genetic and environmental factors. In contrast to childhood neurodevelopmental conditions such as autism and intellectual disability, there are no clinical practice guidelines for applying genetic testing in the context of these conditions. But genetic counseling and genetic testing are not synonymous, and people who live with psychiatric disorders and their family members are often interested in what psychiatric genetic counseling can offer. Further, research shows that it can improve outcomes like empowerment for this population. Despite this, psychiatric genetic counseling is not yet routinely or widely offered. This review describes the state of the evidence about the process and outcomes of psychiatric genetic counseling, focusing on its clinical implications and remaining research gaps.
精神障碍，如精神分裂症、抑郁症、焦虑症和双相情感障碍，是常见的疾病，是由遗传和环境因素的复杂和异质组合引起的。与儿童神经发育状况（如自闭症和智力残疾）不同，这些情况下并没有应用基因检测的临床实践指南。但是，遗传咨询和基因检测不是同义词，患有精神障碍的人和他们的家庭成员通常对精神科遗传咨询能提供什么感兴趣。此外，研究表明，这可以改善这一人群的赋权等结果。尽管如此，精神科遗传咨询还没有常规或广泛提供。本综述描述了关于精神科遗传咨询过程和结果的证据状况，重点介绍了其临床意义和尚存的研究空白。
