Riaz Saad, Ali Murad, Hussain Manzoor, Hassan Zahid, Na Hamidullah, Ur-Rehman Zia, Ali Sajjad, Ahmed Izhar, Shahzad Shahid
Internal Medicine, Mardan Medical Complex, Mardan, PAK.
Pediatric Cardiology, Maqsood Medical Complex (MMC) General Hospital, Peshawar, PAK.
Cureus. 2025 May 24;17(5):e84742. doi: 10.7759/cureus.84742. eCollection 2025 May.
Hypomagnesemia has been linked to stroke development through its effects on blood vessel function and nerve cell excitability, but data from South Asia are limited. The aim of this study was to determine the prevalence of hypomagnesemia in patients with acute ischemic stroke and its associated risk factors at a tertiary care hospital in Pakistan.
The study employed a cross-sectional design, conducted from November 2020 to June 2021, and enrolled 137 consecutive stroke patients. Hypomagnesemia was defined as serum magnesium levels less than 1.82 mg/dL. SPSS software v24 (IBM Corp., Armonk, NY) was used to analyze the association between hypomagnesemia and various demographic and clinical factors.
Hypomagnesemia was found to be present in 48.9% of ischemic stroke patients. The most common associated comorbidities were hypertension and type 2 diabetes mellitus. The study discovered a strong correlation between hypertension and stroke, and 61.1% of the hypertensive patients with stroke had hypomagnesemia. Hypomagnesemia was found in 18.5% of smokers compared to 56.4% of non-smokers, indicating an inverse connection with smoking. The prevalence of hypomagnesemia was similar in males and females and across age groups.
Hypomagnesemia was present in nearly half of the patients with acute ischemic stroke, and hypertension was a strong predictor. Further study is warranted for the lower prevalence of hypomagnesemia among smokers. Secondary strokes may be prevented in high-risk individuals by routine magnesium screening and supplementation.
低镁血症通过对血管功能和神经细胞兴奋性的影响与中风的发生有关，但来自南亚的数据有限。本研究的目的是确定巴基斯坦一家三级护理医院急性缺血性中风患者中低镁血症的患病率及其相关危险因素。
该研究采用横断面设计，于2020年11月至2021年6月进行，纳入了137例连续的中风患者。低镁血症定义为血清镁水平低于1.82mg/dL。使用SPSS软件v24（IBM公司，纽约州阿蒙克）分析低镁血症与各种人口统计学和临床因素之间的关联。
发现48.9%的缺血性中风患者存在低镁血症。最常见的相关合并症是高血压和2型糖尿病。研究发现高血压与中风之间存在很强的相关性，61.1%的中风高血压患者有低镁血症。吸烟者中低镁血症的发生率为18.5%，非吸烟者为56.4%，表明与吸烟呈负相关（反向关联）。低镁血症在男性和女性以及各年龄组中的患病率相似。
近一半的急性缺血性中风患者存在低镁血症，高血压是一个强有力的预测因素。对于吸烟者中低镁血症患病率较低的情况，有必要进一步研究。通过常规的镁筛查和补充，可能预防高危个体的继发性中风。
