Center S A, Wilkinson E, Smith C A, Erb H, Lewis R M
J Am Vet Med Assoc. 1985 Oct 15;187(8):820-4.
The 24-hour urine protein/creatinine (U[P/C]) ratio was examined in 19 healthy dogs and in 38 dogs with protein-losing nephropathies. A positive correlation existed between the U(P/C) ratio and the 24-hour urine protein output per kilogram of body weight. The U(P/C) ratio in 18 of 19 healthy dogs was less than 0.2; one dog had a ratio of 0.38. The median U(P/C) ratio in dogs with glomerulonephritis (n = 26) and amyloidosis (n = 6) was 5.73 and 22.50, respectively. The median U(P/C) ratio in dogs with chronic interstitial nephritis (n = 6) was 2.89. In the presence of hypoalbuminemia (albumin less than or equal to 1.5 g/dl), a U/(P/C) ratio greater than 1 indicated a nephrotic syndrome. Severe protein-losing nephropathies (ie, severe glomerulonephritis and amyloidosis) were characterized by U(P/C) ratios greater than 10 and urine protein values exceeding 159 mg/kg/day. The 24-hour U/(P/C) may be more sensitive than the 24-hour urine protein output per kilogram of body weight in the detection of mild glomerular disease. Abnormal U(P/C) ratios were present in 5 dogs, 2 with glomerulonephritis and 3 with chronic interstitial nephritis; that had normal or mildly increased 24-hour urine protein output.
对19只健康犬和38只患有失蛋白性肾病的犬进行了24小时尿蛋白/肌酐（U[P/C]）比值检测。U（P/C）比值与每千克体重的24小时尿蛋白排出量之间存在正相关。19只健康犬中有18只的U（P/C）比值小于0.2；1只犬的比值为0.38。患有肾小球肾炎（n = 26）和淀粉样变性（n = 6）的犬的U（P/C）比值中位数分别为5.73和22.50。患有慢性间质性肾炎（n = 6）的犬的U（P/C）比值中位数为2.89。在存在低白蛋白血症（白蛋白小于或等于1.5 g/dl）的情况下，U/（P/C）比值大于1表明为肾病综合征。严重的失蛋白性肾病（即严重肾小球肾炎和淀粉样变性）的特征是U（P/C）比值大于10且尿蛋白值超过159 mg/kg/天。在检测轻度肾小球疾病时，24小时U/（P/C）比值可能比每千克体重的24小时尿蛋白排出量更敏感。5只犬的U（P/C）比值异常，其中2只患有肾小球肾炎，3只患有慢性间质性肾炎；这些犬的24小时尿蛋白排出量正常或轻度增加。
