Wang Qian, Wang Lihao, Teng Chi, Dong Chenqing, Wang Xiaoming, Yang Bingyou, Kuang Haixue, Sun Yanping
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
Key Laboratory of Basic and Application Research of Beiyao, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
Int J Biol Macromol. 2025 Aug;319(Pt 2):145462. doi: 10.1016/j.ijbiomac.2025.145462. Epub 2025 Jun 22.
The genus Grateloupia is the largest member of the Grateloupiaceae family and is widely distributed in coastal areas worldwide. In China, it is called "Wugongzao" due to its resemblance to a centipede in morphology. As a type of sea vegetables, it has excellent chewiness and refreshing mouthfeel. Additionally, it has medicinal values such as clearing heat, detoxification, and insect repellent in China. As one of its main biologically active macromolecules, the genus Grateloupia polysaccharides (TGGPs) possess a variety of pharmacological activities, such as antioxidant, antiviral, antibacterial, immunomodulatory, anti-tumor, hypoglycemic, and probiotic activities. TGGPs are highly active and non-toxic, making them indispensable in both the food industry and the medical field. However, there is currently no review article that systematically summarizes them. This review discusses and summarizes the latest developments and shortcomings in the extraction, isolation and purification, chemical structure and modification, and bioactivities of TGGPs. At the same time, the utilization and production of TGGPs in medicine, functional foods, cosmetics, agriculture and fisheries are also reported. We believe this work will provide new and valuable insights for future research on TGGPs potential applications.
蜈蚣藻属是蜈蚣藻科中最大的成员，广泛分布于世界各地的沿海地区。在中国，因其形态类似蜈蚣而被称为“蜈蚣藻”。作为一种海菜，它具有极佳的嚼劲和清爽的口感。此外，在中国它还具有清热、解毒、驱虫等药用价值。作为其主要的生物活性大分子之一，蜈蚣藻属多糖（TGGPs）具有多种药理活性，如抗氧化、抗病毒、抗菌、免疫调节、抗肿瘤、降血糖和益生菌活性等。TGGPs活性高且无毒，使其在食品工业和医学领域都不可或缺。然而，目前尚无系统总结它们的综述文章。本综述讨论并总结了TGGPs在提取、分离纯化、化学结构与修饰以及生物活性方面的最新进展和不足。同时，还报道了TGGPs在医药、功能性食品、化妆品、农业和渔业中的利用与生产情况。我们相信这项工作将为未来TGGPs潜在应用的研究提供新的有价值的见解。
