Simons F E, Luciuk G H, Simons K J
Am J Dis Child. 1982 Sep;136(9):790-3. doi: 10.1001/archpedi.1982.03970450032008.
Theo-Dur, a sustained-release theophylline formulation, was administered every 12 hours for three months to ten asthmatic children aged 3 to 7 years, with no evidence of adverse reaction or tolerance. There was significant temporal variation in serum theophylline concentrations. The mean difference between the peak and trough concentrations was 6.5 micrograms/mL (range, 3 to 14 micrograms/mL) in a 12-hour period. Serum theophylline concentrations correlated well with pulmonary function test results. Nine or more hours after a Theo-Dur dose, some children needed additional bronchodilator treatment and had impairment of pulmonary function. We recommend that children aged 7 years or younger who are given Theo-Dur have monitoring of predose serum theophylline concentrations, symptoms, and signs, as many will require a dose frequency greater than every 12 hours.
茶喘平，一种茶碱缓释制剂，对10名3至7岁的哮喘儿童每12小时给药一次，持续三个月，未发现不良反应或耐受性证据。血清茶碱浓度存在显著的时间变化。在12小时内，峰浓度与谷浓度之间的平均差值为6.5微克/毫升（范围为3至14微克/毫升）。血清茶碱浓度与肺功能测试结果密切相关。茶喘平给药9小时或更长时间后，一些儿童需要额外的支气管扩张剂治疗，并且肺功能受损。我们建议，接受茶喘平治疗的7岁及以下儿童应监测给药前的血清茶碱浓度、症状和体征，因为许多儿童需要大于每12小时一次的给药频率。
