Li Wenjing, Liu Xiaohua, Li Jingjing
Physical Education College, Shanghai University, Shanghai, China.
School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, United Kingdom.
Front Cell Dev Biol. 2025 Jun 10;13:1589169. doi: 10.3389/fcell.2025.1589169. eCollection 2025.
Stem cells are cells with strong proliferation and differentiation abilities. Among all stem cells, bone marrow mesenchymal stem cells (BMSCs) have been extensively studied. BMSCs have the ability to self-renew and differentiate into nerve cells, and participate in cell migration and survival. These cells can also secrete neurotrophic factors through paracrine pathways to affect neural plasticity. Transplantation of BMSCs can affect neural plasticity and is the main treatment method for stroke or other traumatic brain diseases. This article elaborates on the role of BMSC transplantation in neural plasticity, neurotrophic factors, and synaptic changes, and comprehensively analyzes its potential molecular mechanisms to provide a theoretical basis for clinical treatment of brain diseases.
干细胞是具有强大增殖和分化能力的细胞。在所有干细胞中，骨髓间充质干细胞（BMSCs）已得到广泛研究。BMSCs具有自我更新和分化为神经细胞的能力，并参与细胞迁移和存活。这些细胞还可通过旁分泌途径分泌神经营养因子，以影响神经可塑性。BMSCs移植可影响神经可塑性，是治疗中风或其他创伤性脑疾病的主要方法。本文阐述了BMSC移植在神经可塑性、神经营养因子和突触变化中的作用，并全面分析其潜在分子机制，为脑部疾病的临床治疗提供理论依据。
