细胞因子和活性氧在脑老化中的作用。
Role of cytokines and reactive oxygen species in brain aging.
机构信息
Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
Department of Biomedical Sciences, College of Veterinary Medicine, University of Georgia, Athens, GA 30602, USA.
出版信息
Mech Ageing Dev. 2023 Sep;214:111855. doi: 10.1016/j.mad.2023.111855. Epub 2023 Aug 3.
Abstract
Aging is a complex process that produces profound effects on the brain. Although a number of external factors can promote the initiation and progression of brain aging, peripheral and central changes in the immune cells with time, also play an important role. Immunosenescence, which is an age-associated decline in immune function and Inflammaging, a low-grade inflammatory state in the aging brain contribute to an elevation in cytokine and reactive oxygen species production. In this review, we focus on the pro-inflammatory state that is established in the brain as a consequence of these two phenomena and the resulting detrimental changes in brain structure, function and repair that lead to a decline in central and neuroendocrine function.
摘要
衰老是一个复杂的过程，对大脑产生深远的影响。尽管许多外部因素可以促进大脑衰老的发生和发展，但随着时间的推移，免疫细胞在身体外周和中枢的变化也起着重要的作用。免疫衰老（与年龄相关的免疫功能下降）和炎症衰老（衰老大脑中的低度炎症状态）会导致细胞因子和活性氧的产生增加。在这篇综述中，我们重点讨论了这两种现象导致的大脑中促炎状态的建立，以及由此导致的大脑结构、功能和修复的有害变化，从而导致中枢和神经内分泌功能下降。
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