Kpatsi Stephen, Daniels Joseph, Kyei Kofi Adesi, Vanderpuye Verna
National Radiotherapy, Oncology and Nuclear Medicine Centre, Korle Bu Teaching Hospital, Accra, Ghana.
https://orcid.org/0009-0005-8954-0509.
Ecancermedicalscience. 2025 May 27;19:1912. doi: 10.3332/ecancer.2025.1912. eCollection 2025.
Dermatofibrosarcoma protuberans (DFSPs) is a low-grade mesenchymal tumour of dermal origin. Although lung metastasis is common, primary breast involvement is a very rare occurrence. The head and neck region, trunk and extremities are the common primary sites even though any site of the body may be potentially involved. Complete surgical resection with negative margins is the standard of care for nonmetastatic cases of DFSP. To the best of our knowledge, there have been no previous reports of metastatic DFSP of the breast to the lungs among male patients in sub-Saharan Africa. This case report presents data on a 32-year-old male with metastatic DFSP of the left breast to the lungs who was successfully treated with 800 mg daily imatinib mesylate therapy and achieved a complete radiological and clinical response after 1 year of palliative therapy.
隆突性皮肤纤维肉瘤（DFSPs）是一种起源于真皮的低度间叶性肿瘤。虽然肺转移很常见，但原发性乳腺受累极为罕见。头颈部、躯干和四肢是常见的原发部位，尽管身体的任何部位都有可能受累。对于非转移性DFSP病例，切缘阴性的完整手术切除是标准治疗方法。据我们所知，撒哈拉以南非洲地区此前尚无男性患者乳腺DFSP转移至肺部的报道。本病例报告介绍了一名32岁男性患者的数据，该患者左乳DFSP转移至肺部，接受每日800毫克甲磺酸伊马替尼治疗后成功治愈，姑息治疗1年后实现了影像学和临床完全缓解。
