Shi Yue, Zeng Muling, Casals Eudald, Casals Gregori, Liu Ning
Gynecology and Oncology Department of the Second Hospital of Jilin University, Changchun, 130041, China.
Materials Science Institute of Barcelona (ICMAB-CSIC), Bellaterra, 08193, Spain.
Small. 2025 Jun 25:e2504366. doi: 10.1002/smll.202504366.
Metal-organic frameworks (MOFs) and Covalent-organic frameworks (COFs) are promising materials for biomedical applications due to their high surface area, tunable porosity, and functional versatility. Functionalized or nanoparticle-containing MOFs and COFs have been largely explored in preclinical studies for drug delivery, photodynamic and photothermal therapies, and ROS generation targeting cancer cells, among others. Additionally, they have shown potential as carriers of imaging agents for precise biomarker identification and tumor detection. However, the application of nanomaterials in medicine, including MOFs and COFs, still does not meet the expectations set more than two decades ago. This is particularly important in the maternal-fetal field, where substantial maternal health risks during pregnancy and childbirth affect many women. Only recently a range of preliminary studies exist, as these risks have traditionally been viewed as inherent to pregnancy, leaving significant gaps in innovative solutions for women's health that nanomaterials have the potential to bridge. This review addresses this critical need, offering a summary of current research in obstetrics and gynecology and maternal-fetal applications of MOFs and COFs, identifying gaps, and aiming to guide future research to expand nanomedicine's impact in these areas.
金属有机框架材料（MOFs）和共价有机框架材料（COFs）因其高比表面积、可调孔隙率和功能多样性，是生物医学应用中很有前景的材料。功能化的或含纳米颗粒的MOFs和COFs在临床前研究中已被大量探索用于药物递送、光动力和光热疗法以及针对癌细胞的活性氧生成等。此外，它们还显示出作为成像剂载体用于精确生物标志物识别和肿瘤检测的潜力。然而，包括MOFs和COFs在内的纳米材料在医学上的应用仍未达到二十多年前所设定的期望。这在母胎领域尤为重要，因为孕期和分娩期间的重大孕产妇健康风险影响着许多女性。直到最近才有一系列初步研究，因为这些风险传统上被视为怀孕所固有的，在纳米材料有潜力填补的女性健康创新解决方案方面留下了重大空白。本综述满足了这一关键需求，总结了MOFs和COFs在妇产科及母胎应用方面的当前研究，找出差距，并旨在指导未来研究以扩大纳米医学在这些领域的影响。
