Vangroenweghe Frédéric, Matthijs Thomas, Sinnaeve Marnix
Elanco Animal Health Benelux, BU Swine & Ruminants, Generaal Lemanstraat 55/3, 2018 Antwerpen, Belgium.
Unit of Porcine Health Management, Department of Internal Medicine-Reproduction-Population Medicine, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Antibiotics (Basel). 2025 May 27;14(6):547. doi: 10.3390/antibiotics14060547.
BACKGROUND/OBJECTIVES: In swine production, the post-weaning period has been identified as one of the most challenging and stressful periods in the life of a piglet due to changes in its environment and feeding regimen. During this period, piglets might undergo infectious challenges with enterotoxigenic (ETEC) resulting in post-weaning diarrhea (PWD), and meningitis due to . Therefore, metaphylactic and curative antimicrobial therapy is frequently applied, which leads to an increased treatment incidence per 100 days at risk (TI).
Here, we report the results of an antimicrobial coaching trajectory in a 1000-sow farm with high antimicrobial use during the post-weaning period. For a period of 21 weeks, we evaluated the effect of an oral live avirulent F4F18 vaccine (Coliprotec F4F18; Elanco AH) for the active immunization of piglets against PWD caused by F4- and F18-ETEC on the reduction in antimicrobial use during the post-weaning period. A 1000-sow farm with PIC sows operating in a 1-week BMS was rated as an 'attention farm' at the level of the post-weaning period according to the Antimicrobial Consumption and Resistance in Animals (AMCRA) benchmark reporting tool. To analyze the specific approach towards antimicrobial use and the related post-weaning pathology, a farm visit including a biosecurity check was carried out together with all associated stakeholders. Subsequently, an antimicrobial coaching trajectory was utilized to follow-up on the improvement of the reduction in antimicrobial use after implementation of the various pieces of advice.
For analytical purposes, we compared the results obtained in period 1 (P1; vaccination week 1-6) to period 2 (P2; vaccination week 7-21), since practical field experience has demonstrated that a 'stabilization period' of about 6 weeks is necessary to obtain the maximal effect of vaccination. There was a significant reduction in mortality (5.7% to 2.0%) and improvement in the average daily weight gain (366 g/d to 392 g/d) following vaccination, with a simultaneous reduction in the number of days in nursery (45 days to 38 days). Meanwhile, the weight at the end of nursery remained at a similar level. There was a clinically relevant though non-significant decrease in the TI (32.8 days to 20.6 days). Overall, the implementation of all measures resulted in a positive ROI of 2.72 per piglet.
The implementation of several biosecurity measures in combination with the use of an oral live avirulent F4F18 vaccine (Coliprotec F4F18) could improve performance parameters and reduce mortality, while reducing the number of days in nursery and the TI. Overall, a positive return on investment of 2.72 could be obtained per piglet produced under these improved conditions.
背景/目的：在养猪生产中，断奶后时期被认为是仔猪生命中最具挑战性和压力的时期之一，这是由于其环境和喂养方式发生了变化。在此期间，仔猪可能会受到产肠毒素大肠杆菌（ETEC）的感染挑战，从而导致断奶后腹泻（PWD），以及因[此处原文缺失病原体]导致的脑膜炎。因此，预防性和治疗性抗菌治疗经常被应用，这导致每100天风险期的治疗发病率（TI）增加。
在此，我们报告了在一个断奶后时期抗菌药物使用量高的1000头母猪养殖场中进行的抗菌药物指导轨迹的结果。在21周的时间里，我们评估了口服无毒F4F18活疫苗（Coliprotec F4F18；英特威动物保健）对仔猪主动免疫以抵抗由F4和F18 - ETEC引起的PWD对断奶后时期抗菌药物使用减少的影响。一个拥有PIC母猪且采用1周批次管理系统的1000头母猪养殖场，根据动物抗菌药物消费与耐药性（AMCRA）基准报告工具，在断奶后时期被评为“重点关注养殖场”。为了分析抗菌药物使用的具体方法以及相关的断奶后病理情况，与所有相关利益相关者一起进行了一次包括生物安全检查的农场访问。随后，利用抗菌药物指导轨迹对实施各项建议后抗菌药物使用减少情况的改善进行跟踪。
出于分析目的，我们将第1阶段（P1；接种疫苗第1 - 6周）和第2阶段（P2；接种疫苗第7 - 21周）获得的结果进行了比较，因为实际现场经验表明，大约6周的“稳定期”对于获得疫苗接种的最大效果是必要的。接种疫苗后，死亡率显著降低（从5.7%降至2.0%），平均日增重有所改善（从366克/天增至392克/天），同时保育天数减少（从45天减至38天）。与此同时，保育期末的体重保持在相似水平。TI有临床相关但不显著的下降（从32.8天降至20.6天）。总体而言，所有措施的实施导致每头仔猪的投资回报率为2.72。
结合使用口服无毒F4F18活疫苗（Coliprotec F4F18）实施多项生物安全措施，可以改善性能参数并降低死亡率，同时减少保育天数和TI。总体而言，在这些改善的条件下，每生产一头仔猪可获得2.72的正投资回报率。
