Ramatla Tsepo, Jane Nkhebenyane, Dineo Mohapi, Mpho Tawana, Tshegofatso Motlhaoloa, Khasapane Ntelekwane George
Centre for Applied Food Safety and Biotechnology, Department of Life Sciences, Central University of Technology, 1 Park Road, Bloemfontein 9300, South Africa.
Department of Zoology and Entomology, University of the Free State, Private Bag x13, Phuthaditjhaba 9866, South Africa.
Antibiotics (Basel). 2025 May 31;14(6):568. doi: 10.3390/antibiotics14060568.
Shiga toxin-producing (STEC) are important foodborne pathogens that cause serious public health consequences worldwide. This study conducted a systematic review and meta-analysis of the global prevalence of antibiotic resistance and STEC in chickens. The assessment of previous study records was carried out following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Heterogeneity between studies was assessed using Cochrane's Q test and I test statistics based on the random effects model, and comprehensive meta-analysis (CMA) software v4.0 was used to analyse the pooled prevalence estimate (PPE) of antibiotic resistance and STEC in chickens. A total of 61 studies comprising 823 STEC from 18 countries were included in this study. The overall pooled prevalence of STEC was 8.9% (95% CI: 0.620-0.126). m-PCR assay showed the highest PPE of 21.0% (95%: 0.088-0.420). had the higher PPE of 12.9% (95%: 0.081-0.199), while had a PPE of 11.8% (95%: 0.077-0.176). Furthermore, the serotype O157 had the higher PPE of 80.5% (95%: 0.520-0.940). The isolates were resistant to the following antibiotics: amoxicillin and clavulanic acid, chloramphenicol, tetracycline, ciprofloxacin, gentamycin, ampicillin, neomycin, and amoxicillin. These findings may assist in the prevention and control of STEC in chickens globally. To minimise the spread of STEC and antibiotic resistance, future foodborne pathogen prevention and control programmes should prioritise increasing laboratory capacity for the early identification of antibiotic resistance.
产志贺毒素大肠杆菌（STEC）是重要的食源性病原体，在全球范围内造成严重的公共卫生后果。本研究对全球鸡群中抗生素耐药性和STEC的流行情况进行了系统评价和荟萃分析。根据系统评价和荟萃分析的首选报告项目（PRISMA）指南，对先前的研究记录进行了评估。使用基于随机效应模型的Cochrane's Q检验和I检验统计量评估研究之间的异质性，并使用综合荟萃分析（CMA）软件v4.0分析鸡群中抗生素耐药性和STEC的合并流行率估计值（PPE）。本研究共纳入了来自18个国家的61项研究，包括823株STEC。STEC的总体合并流行率为8.9%（95%CI：0.620 - 0.126）。多重PCR检测显示最高PPE为21.0%（95%：0.088 - 0.420）。[此处原文缺失具体检测方法名称]的PPE较高，为12.9%（95%：0.081 - 0.199），而[此处原文缺失具体检测方法名称]的PPE为11.8%（95%：0.077 - 0.176）。此外，血清型O157的PPE较高，为80.5%（95%：0.520 - 0.940）。分离株对以下抗生素耐药：阿莫西林和克拉维酸、氯霉素、四环素、环丙沙星、庆大霉素、氨苄西林、新霉素和阿莫西林。这些发现可能有助于全球范围内鸡群中STEC的预防和控制。为尽量减少STEC和抗生素耐药性的传播，未来的食源性病原体预防和控制计划应优先提高早期识别抗生素耐药性的实验室能力。
