McBroom R J, Hayes W C, Edwards W T, Goldberg R P, White A A
J Bone Joint Surg Am. 1985 Oct;67(8):1206-14.
We performed quantitative computed tomography in vitro on the first and third lumbar vertebrae in human cadavera using a dibasic potassium phosphate phantom for calibration. The quantitative computed-tomography numbers exhibited a significant positive correlation (R2 = 0.89, p less than 0.0001) with direct measurements of the apparent density of the vertebral trabecular bone. We also conducted uniaxial compression tests to failure of the vertebral bodies after removal of the posterior elements, and found that vertebral compressive strength was also correlated at a high level of significance (R2 = 0.82, p less than 0.0001) with direct measurement of the trabecular apparent density. These findings suggested the possibility that the quantitative computed-tomography values might be directly predictive of vertebral compressive strength. However, when we correlated the quantitative computed-tomography values directly with vertebral compressive strength, the results (R2 = 0.46, p less than 0.061) were suggestive but not quite significant. All vertebral bodies failed by compression of the end-plate, suggesting only a modest structural role for the cortical shell under these loading conditions. This was confirmed by comparing the compressive load to failure of twenty additional pairs of vertebrae that were tested with and without an intact vertebral cortex. Removal of the cortex was associated with approximately 10 per cent reduction in vertebral load to failure.
我们使用磷酸氢二钾模型进行校准，对人体尸体的第一和第三腰椎进行了体外定量计算机断层扫描。定量计算机断层扫描数值与椎骨小梁骨表观密度的直接测量值呈现出显著的正相关（R2 = 0.89，p小于0.0001）。在去除后部结构后，我们还对椎体进行了单轴压缩试验直至破坏，发现椎体抗压强度与小梁表观密度的直接测量值也具有高度显著的相关性（R2 = 0.82，p小于0.0001）。这些发现提示定量计算机断层扫描值可能直接预测椎体抗压强度。然而，当我们将定量计算机断层扫描值与椎体抗压强度直接关联时，结果（R2 = 0.46，p小于0.061）具有提示性但不太显著。所有椎体均因终板受压而破坏，表明在这些加载条件下皮质壳的结构作用较小。通过比较另外二十对椎体在有完整椎体皮质和无完整椎体皮质情况下的破坏抗压载荷，这一点得到了证实。去除皮质与椎体破坏载荷降低约10%相关。
