Lang S M, Moyle D D, Berg E W, Detorie N, Gilpin A T, Pappas N J, Reynolds J C, Tkacik M, Waldron R L
Department of Bioengineering, Clemson University, South Carolina 29634.
J Bone Joint Surg Am. 1988 Dec;70(10):1531-8.
We tried to determine whether mineral-equivalent measurements that were obtained using computed tomography could be used to predict the mechanical properties of vertebral trabecular bone. Vertebral bodies that had been obtained during routine autopsy were evaluated by computed tomography. The mechanical properties of the vertebral trabecular bone were determined by subjecting cylindrical specimens to simple compression until failure occurred. The ultimate strength and elastic modulus were determined from load time curves, using constant displacement rate loading. Atomic absorption spectrophotometry was used to determine the weight per cent calcium of each specimen, and quantitative light microscopy was used to determine area fraction bone. Significant positive correlations were found between the observed mechanical properties of the trabecular bone and the equivalent mineral density as measured by computed tomography. Compressive strength (r = 0.720), elastic modulus (r = 0.574), trabecular calcium density (r = 0.780), and area fraction bone (r = 0.579) were all correlated with the equivalent mineral density.
我们试图确定通过计算机断层扫描获得的矿物等效测量值是否可用于预测椎骨小梁骨的力学性能。对在常规尸检期间获取的椎体进行计算机断层扫描评估。通过对圆柱形标本进行简单压缩直至发生破坏来确定椎骨小梁骨的力学性能。使用恒定位移速率加载，从载荷-时间曲线确定极限强度和弹性模量。采用原子吸收分光光度法测定每个标本的钙重量百分比，并使用定量光学显微镜测定骨面积分数。发现小梁骨的观察到的力学性能与计算机断层扫描测量的等效矿物质密度之间存在显著正相关。抗压强度（r = 0.720）、弹性模量（r = 0.574）、小梁钙密度（r = 0.780）和骨面积分数（r = 0.579）均与等效矿物质密度相关。
