Tao Yubo, Du Jinbao, Hu Tong, Li Peng, Pan Ling, Kong Fangong, Zhang Jingfa
State Key Laboratory of Green Papermaking and Resource Recycling, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Key Laboratory of Bio-Based Material Science & Technology, Northeast Forestry University, Harbin 150040, China.
Gels. 2025 Jun 16;11(6):458. doi: 10.3390/gels11060458.
The development of printable, biocompatible, biodegradable, and cost-effective bioinks, or biomaterial inks, remains a focal point in extrusion-based bioprinting research. In this study, fish gelatin (FG) was reinforced with microcrystalline cellulose (MCC) to formulate biomaterial inks. These FG/MCC composite inks were fabricated into 3D scaffolds using an extrusion bioprinter. The influence of MCC concentration on printability was systematically evaluated. Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses confirmed the formation of hydrogen bonds between MCC and FG, indicating molecular-level interactions. Notably, MCC incorporation enhanced the rheological properties of the ink and significantly improved the compressive strength of printed scaffolds. Furthermore, MCC content modulated key scaffold characteristics, including porosity, degradation rate, swelling behavior, and microarchitecture. These findings demonstrate that FG/MCC composite hydrogels exhibit optimal properties for extrusion-based 3D bioprinting, offering a promising platform for tissue engineering applications.
可打印、生物相容、可生物降解且具有成本效益的生物墨水或生物材料墨水的开发，仍然是基于挤出的生物打印研究的重点。在本研究中，微晶纤维素（MCC）增强了鱼明胶（FG）以配制生物材料墨水。使用挤出生物打印机将这些FG/MCC复合墨水制成3D支架。系统评估了MCC浓度对可打印性的影响。傅里叶变换红外光谱（FTIR）和X射线衍射（XRD）分析证实了MCC和FG之间形成了氢键，表明存在分子水平的相互作用。值得注意的是，加入MCC增强了墨水的流变性能，并显著提高了打印支架的抗压强度。此外，MCC含量调节了关键的支架特性，包括孔隙率、降解速率、溶胀行为和微观结构。这些发现表明，FG/MCC复合水凝胶在基于挤出的3D生物打印中表现出最佳性能，为组织工程应用提供了一个有前景的平台。
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