Pan Ling, Li Peng, Tao Yubo
College of Material Science and Engineering, Northeast Forestry University, Harbin 150040, China.
State Key Laboratory of Biobased Material and Green Papermaking, Qilu University of Technology, Shandong Academy of Sciences, Jinan 250353, China.
Materials (Basel). 2020 Sep 30;13(19):4370. doi: 10.3390/ma13194370.
As a natural macromolecule-based biomaterial, fish gelatin is used in medical materials for its low pathogen infection risk. However, because of poor mechanical properties, its application has been limited. In this study, microcrystalline cellulose-reinforced fish gelatin (FG/MCC) composite films were prepared with a biological cross-linking agent (genipin) under ultrasonic treatment. SEM micrographs showed that the smooth microstructure of FG film became increasingly disordered with the addition of MCC. The infrared spectrum analysis (FTIR) demonstrated the existence of hydrogen bond interaction between MCC and FG. Compared with the pure FG film, the tensile strength (TS) and modulus of elasticity (MOE) of composite films with MCC were improved, and the elongation at break (EAB) and swelling ratios (SR) were decreased. Ultrasonic treatment could further improve TS, MOE, and SR. When the composite film was prepared with 15% MCC and treated with ultrasound, the TS and MOE increased by 115% and 227%, respectively, while the EAB decreased by 35% and the SR decreased by 4% in comparison with pure FG films. Thermo-gravimetric analysis (TGA) showed that the FG/MCC composite films were stable below 100 °C. The above results indicate that the FG/MCC films have optimistic application prospects in the biomedical field.
作为一种天然的基于大分子的生物材料，鱼明胶因其较低的病原体感染风险而被用于医疗材料中。然而，由于其机械性能较差，其应用受到了限制。在本研究中，在超声处理下，使用生物交联剂（京尼平）制备了微晶纤维素增强鱼明胶（FG/MCC）复合膜。扫描电子显微镜图像显示，随着MCC的添加，FG膜光滑的微观结构变得越来越无序。红外光谱分析（FTIR）表明MCC与FG之间存在氢键相互作用。与纯FG膜相比，含MCC的复合膜的拉伸强度（TS）和弹性模量（MOE）有所提高，而断裂伸长率（EAB）和溶胀率（SR）降低。超声处理可进一步提高TS、MOE和SR。当复合膜用15%的MCC制备并经超声处理时，与纯FG膜相比，TS和MOE分别提高了115%和227%，而EAB降低了35%，SR降低了4%。热重分析（TGA）表明，FG/MCC复合膜在100℃以下是稳定的。上述结果表明，FG/MCC膜在生物医学领域具有乐观的应用前景。
