Suppr超能文献

在哥伦比亚:整合毒液组学研究、公民科学与社区赋权。

in Colombia: Integrating Venomics Research, Citizen Science, and Community Empowerment.

作者信息

Rey-Suárez Paola, Rojo Lina Preciado, Gómez-Robles Jeisson, Parra-Moreno Sanin, Pachon-Camelo Erica, Fuentes-Florez Yirlys, Lomonte Bruno, Fernández Julián, Sasa Mahmood, Núñez Vitelbina, Saldarriaga-Cordoba Mónica

机构信息

Grupo de Investigación en Toxinología, Alternativas Terapéuticas y Alimentarias, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 50010, Colombia.

Programa de Biología, Universidad de Antioquia, Medellín 50010, Colombia.

出版信息

Toxins (Basel). 2025 May 27;17(6):268. doi: 10.3390/toxins17060268.

Abstract

Snakebite is a high-priority neglected tropical disease, and a strategic goal based on four pillars has been recommended to reduce mortality and morbidity. One is empowering rural communities through citizen science, education, and engagement. In this study, an integrative approach was used to expand our knowledge of status and characterize its venom. Using citizen science data and field visits to local communities, 99 records of distributed in Antioquia, Chocó, and Córdoba were obtained. Children, young people, and adults recognized as the most common coral snake species in their region, and two specimens were recovered for venomic and Phylogenetic analyses. The venom from Colombia exhibited similar chromatographic and electrophoretic profiles and biological activities and shared nearly identical protein families with Costa Rica. Commercial coral snake antivenoms also recognized and neutralized the whole venom from both countries. However, phylogenetic relationships showed greater divergence with specimens from Costa Rica. Involving communities helps prevent coral snake bites and facilitates access to rare specimens such as , thereby enabling venom analyses, improving antivenom evaluation, and advancing toxinology research for medically significant species.

摘要

蛇咬伤是一种急需关注的被忽视热带病,有人提出了一个基于四大支柱的战略目标,以降低死亡率和发病率。其中之一是通过公民科学、教育和参与增强农村社区的能力。在本研究中,采用了一种综合方法来扩展我们对[蛇种名称]的了解并对其毒液进行表征。利用公民科学数据和对当地社区的实地走访,获得了分布在安蒂奥基亚、乔科和科尔多瓦的99条[蛇种名称]记录。儿童、年轻人和成年人将[蛇种名称]识别为他们所在地区最常见的珊瑚蛇物种,并采集了两个标本用于毒液组学和系统发育分析。来自哥伦比亚的[蛇种名称]毒液表现出相似的色谱和电泳图谱以及生物活性,并且与来自哥斯达黎加的毒液拥有几乎相同的蛋白质家族。商业珊瑚蛇抗蛇毒血清也能识别并中和来自这两个国家的全毒液。然而,系统发育关系表明,与来自哥斯达黎加的标本相比,差异更大。让社区参与有助于预防珊瑚蛇咬伤,并便于获取像[蛇种名称]这样的珍稀标本,从而能够进行毒液分析、改进抗蛇毒血清评估,并推进对具有医学重要性的物种的毒素学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/ffbc4d1d9709/toxins-17-00268-g001.jpg

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验