• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

在哥伦比亚:整合毒液组学研究、公民科学与社区赋权。

in Colombia: Integrating Venomics Research, Citizen Science, and Community Empowerment.

作者信息

Rey-Suárez Paola, Rojo Lina Preciado, Gómez-Robles Jeisson, Parra-Moreno Sanin, Pachon-Camelo Erica, Fuentes-Florez Yirlys, Lomonte Bruno, Fernández Julián, Sasa Mahmood, Núñez Vitelbina, Saldarriaga-Cordoba Mónica

机构信息

Grupo de Investigación en Toxinología, Alternativas Terapéuticas y Alimentarias, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquia, Medellín 50010, Colombia.

Programa de Biología, Universidad de Antioquia, Medellín 50010, Colombia.

出版信息

Toxins (Basel). 2025 May 27;17(6):268. doi: 10.3390/toxins17060268.

DOI:10.3390/toxins17060268
PMID:40559846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12197593/
Abstract

Snakebite is a high-priority neglected tropical disease, and a strategic goal based on four pillars has been recommended to reduce mortality and morbidity. One is empowering rural communities through citizen science, education, and engagement. In this study, an integrative approach was used to expand our knowledge of status and characterize its venom. Using citizen science data and field visits to local communities, 99 records of distributed in Antioquia, Chocó, and Córdoba were obtained. Children, young people, and adults recognized as the most common coral snake species in their region, and two specimens were recovered for venomic and Phylogenetic analyses. The venom from Colombia exhibited similar chromatographic and electrophoretic profiles and biological activities and shared nearly identical protein families with Costa Rica. Commercial coral snake antivenoms also recognized and neutralized the whole venom from both countries. However, phylogenetic relationships showed greater divergence with specimens from Costa Rica. Involving communities helps prevent coral snake bites and facilitates access to rare specimens such as , thereby enabling venom analyses, improving antivenom evaluation, and advancing toxinology research for medically significant species.

摘要

蛇咬伤是一种急需关注的被忽视热带病,有人提出了一个基于四大支柱的战略目标,以降低死亡率和发病率。其中之一是通过公民科学、教育和参与增强农村社区的能力。在本研究中,采用了一种综合方法来扩展我们对[蛇种名称]的了解并对其毒液进行表征。利用公民科学数据和对当地社区的实地走访,获得了分布在安蒂奥基亚、乔科和科尔多瓦的99条[蛇种名称]记录。儿童、年轻人和成年人将[蛇种名称]识别为他们所在地区最常见的珊瑚蛇物种,并采集了两个标本用于毒液组学和系统发育分析。来自哥伦比亚的[蛇种名称]毒液表现出相似的色谱和电泳图谱以及生物活性,并且与来自哥斯达黎加的毒液拥有几乎相同的蛋白质家族。商业珊瑚蛇抗蛇毒血清也能识别并中和来自这两个国家的全毒液。然而,系统发育关系表明,与来自哥斯达黎加的标本相比,差异更大。让社区参与有助于预防珊瑚蛇咬伤,并便于获取像[蛇种名称]这样的珍稀标本,从而能够进行毒液分析、改进抗蛇毒血清评估,并推进对具有医学重要性的物种的毒素学研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/f2e48d5dc020/toxins-17-00268-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/ffbc4d1d9709/toxins-17-00268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/e57d8628b98a/toxins-17-00268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/d3e257a25d83/toxins-17-00268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/a6e1b831b732/toxins-17-00268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/e465b64bdf80/toxins-17-00268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/a5cd52d3b98c/toxins-17-00268-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/f2e48d5dc020/toxins-17-00268-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/ffbc4d1d9709/toxins-17-00268-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/e57d8628b98a/toxins-17-00268-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/d3e257a25d83/toxins-17-00268-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/a6e1b831b732/toxins-17-00268-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/e465b64bdf80/toxins-17-00268-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/a5cd52d3b98c/toxins-17-00268-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/07e9/12197593/f2e48d5dc020/toxins-17-00268-g007.jpg

相似文献

1
in Colombia: Integrating Venomics Research, Citizen Science, and Community Empowerment.在哥伦比亚:整合毒液组学研究、公民科学与社区赋权。
Toxins (Basel). 2025 May 27;17(6):268. doi: 10.3390/toxins17060268.
2
Assessment of venom variation and phylogenetic relationships of Micrurus dumerilii from three different regions of Colombia.对来自哥伦比亚三个不同地区的杜氏珊瑚蛇毒液变异和系统发育关系的评估。
Biochimie. 2025 Aug;235:93-105. doi: 10.1016/j.biochi.2025.06.003. Epub 2025 Jun 9.
3
Integrative characterization of the venom of the coral snake Micrurus dumerilii (Elapidae) from Colombia: Proteome, toxicity, and cross-neutralization by antivenom.哥伦比亚杜氏珊瑚蛇(眼镜蛇科)毒液的综合特征:蛋白质组、毒性及抗蛇毒血清的交叉中和作用
J Proteomics. 2016 Mar 16;136:262-73. doi: 10.1016/j.jprot.2016.02.006. Epub 2016 Feb 12.
4
Knowledge about Snake Venoms and Toxins from Colombia: A Systematic Review.哥伦比亚蛇毒和毒素知识:系统评价。
Toxins (Basel). 2023 Nov 15;15(11):658. doi: 10.3390/toxins15110658.
5
Proteomic and biological characterization of the venom of the redtail coral snake, Micrurus mipartitus (Elapidae), from Colombia and Costa Rica.对产自哥伦比亚和哥斯达黎加的红尾珊瑚蛇(Micrurus mipartitus,Elapidae 科)毒液的蛋白质组学和生物学特性进行了研究。
J Proteomics. 2011 Dec 21;75(2):655-67. doi: 10.1016/j.jprot.2011.09.003. Epub 2011 Sep 23.
6
Antivenom for European Vipera species envenoming.用于欧洲蝰蛇属物种咬伤的抗蛇毒血清。
Clin Toxicol (Phila). 2017 Jul;55(6):557-568. doi: 10.1080/15563650.2017.1300261. Epub 2017 Mar 28.
7
First Insights into the Venom Composition of Two Ecuadorian Coral Snakes.初探两种厄瓜多尔珊瑚蛇的毒液组成。
Int J Mol Sci. 2022 Nov 24;23(23):14686. doi: 10.3390/ijms232314686.
8
Systematic review and meta-analysis on the efficacy of Indian polyvalent antivenom against the Indian snakes of clinical significance.系统评价和荟萃分析印度多价抗蛇毒血清对具有临床意义的印度蛇类的疗效。
Arch Toxicol. 2024 Feb;98(2):375-393. doi: 10.1007/s00204-023-03643-9. Epub 2023 Dec 28.
9
Neutralization of two North American coral snake venoms with United States and Mexican antivenoms.用美国和墨西哥抗蛇毒血清中和两种北美珊瑚蛇毒液。
Toxicon. 2008 Feb;51(2):297-303. doi: 10.1016/j.toxicon.2007.10.004. Epub 2007 Oct 13.
10
Immunological cross-recognition and neutralization studies of Micrurus mipartitus and Micrurus dumerilii venoms by two therapeutic equine antivenoms.两种治疗性马抗蛇毒血清对米氏珊瑚蛇和杜氏珊瑚蛇毒液的免疫交叉识别及中和研究
Biologicals. 2020 Nov;68:40-45. doi: 10.1016/j.biologicals.2020.08.011. Epub 2020 Sep 11.

本文引用的文献

1
National Action Plan for the prevention and control of snakebite envenoming in India: strategies and challenges.印度蛇咬伤中毒预防与控制国家行动计划:策略与挑战
Trans R Soc Trop Med Hyg. 2025 May 1;119(5):560-562. doi: 10.1093/trstmh/trae068.
2
Top-down proteomics of venoms from five Micrurus species from Costa Rica: Comparative composition of phospholipase A-rich vs three-finger toxin-rich phenotypes.来自哥斯达黎加五种珊瑚蛇毒液的自上而下蛋白质组学:富含磷脂酶A与富含三指毒素表型的比较组成
Toxicon. 2024 Dec;252:108187. doi: 10.1016/j.toxicon.2024.108187. Epub 2024 Nov 22.
3
Epidemiology and characteristics of coral snake bites reported to the National Poison Data System (2006‒2022).
向国家中毒数据系统报告的珊瑚蛇咬伤的流行病学及特征(2006 - 2022年)
J Am Coll Emerg Physicians Open. 2024 Oct 3;5(5):e13296. doi: 10.1002/emp2.13296. eCollection 2024 Oct.
4
Snakebites by venomous snakes in Brazilian serpentaria and zoos over a 10-year period (2012-2021).巴西蛇园和动物园 10 年间(2012-2021 年)毒蛇咬伤情况。
Toxicon. 2024 Oct;249:108082. doi: 10.1016/j.toxicon.2024.108082. Epub 2024 Aug 30.
5
Presentation, treatment profiles, and outcome of snake bite patients presented in emergency department at a tertiary hospital in Eastern Nepal.尼泊尔东部一家三级医院急诊科收治的蛇咬伤患者的临床表现、治疗情况及预后。
J Family Med Prim Care. 2024 Mar;13(3):1037-1041. doi: 10.4103/jfmpc.jfmpc_1470_23. Epub 2024 Apr 4.
6
Quantifying venom production: A study on Micrurus snakes in Mexico.量化毒液产量:墨西哥响尾蛇研究。
Toxicon. 2024 Mar;240:107658. doi: 10.1016/j.toxicon.2024.107658. Epub 2024 Feb 22.
7
Snakebite prevalence and risk factors in a nomadic population in Samburu County, Kenya: A community-based survey.肯尼亚桑布鲁县游牧民族的蛇伤流行情况和危险因素:一项基于社区的调查。
PLoS Negl Trop Dis. 2024 Jan 2;18(1):e0011678. doi: 10.1371/journal.pntd.0011678. eCollection 2024 Jan.
8
Who are the most affected by Bothrops snakebite envenoming in Brazil? A Clinical-epidemiological profile study among the regions of the country.在巴西,哪些人最容易受到矛头蝮蛇咬伤的影响?一项针对该国各地区的临床流行病学特征研究。
PLoS Negl Trop Dis. 2023 Oct 19;17(10):e0011708. doi: 10.1371/journal.pntd.0011708. eCollection 2023 Oct.
9
In-depth immunorecognition and neutralization analyses of Micrurus mipartitus and M. dumerilii venoms and toxins by a commercial antivenom.深入分析国产抗眼镜蛇毒血清对矛头蝮属(Micrurus)蛇毒和毒素的免疫识别和中和作用。
Biochimie. 2024 Jan;216:120-125. doi: 10.1016/j.biochi.2023.10.009. Epub 2023 Oct 14.
10
Broadening the research landscape in the field of snakebite envenoming: Towards a holistic perspective.拓宽蛇伤研究领域:走向整体观。
Toxicon. 2023 Sep;233:107279. doi: 10.1016/j.toxicon.2023.107279. Epub 2023 Sep 1.